Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3228327..3228961 Replicon chromosome
Accession NZ_CP087392
Organism Pectobacterium parvum strain FN20211

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOZ86_RS14515 Protein ID WP_111778566.1
Coordinates 3228557..3228961 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LOZ86_RS14510 Protein ID WP_165708243.1
Coordinates 3228327..3228557 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOZ86_RS14500 (LOZ86_14500) 3224810..3226702 - 1893 WP_165707585.1 hypothetical protein -
LOZ86_RS14505 (LOZ86_14505) 3226699..3228102 - 1404 WP_230242202.1 hypothetical protein -
LOZ86_RS14510 (LOZ86_14510) 3228327..3228557 + 231 WP_165708243.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LOZ86_RS14515 (LOZ86_14515) 3228557..3228961 + 405 WP_111778566.1 tRNA(fMet)-specific endonuclease VapC Toxin
LOZ86_RS14520 (LOZ86_14520) 3229570..3229791 + 222 WP_181892626.1 hypothetical protein -
LOZ86_RS14525 (LOZ86_14525) 3229857..3231186 + 1330 Protein_2829 IS4 family transposase -
LOZ86_RS14530 (LOZ86_14530) 3231212..3231481 + 270 WP_222850894.1 hypothetical protein -
LOZ86_RS14535 (LOZ86_14535) 3231639..3232836 - 1198 Protein_2831 CmlA/FloR family chloramphenicol efflux MFS transporter -
LOZ86_RS14545 (LOZ86_14545) 3233278..3233430 + 153 Protein_2832 VapC toxin family PIN domain ribonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15074.30 Da        Isoelectric Point: 8.0239

>T225460 WP_111778566.1 NZ_CP087392:3228557-3228961 [Pectobacterium parvum]
MLKYLLDTNICIYTIKNKPQEVRDAFYRHYGQFAISSITLMELIYGAEKSVNPEKNLAVIEGFSARLEVQNYGFDAAVHT
GQIRAELAKQGTPIGPYDAMLAGHARSAGLILVTNNVREFERVPGLRVENWISR

Download         Length: 405 bp

>T225460 NZ_CP121151:2355319-2355422 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8675.73 Da        Isoelectric Point: 4.4091

>AT225460 WP_165708243.1 NZ_CP087392:3228327-3228557 [Pectobacterium parvum]
MEKTTVFKSNRSQAVRLPKAVALPDDVKQVDIVAIGRTRIISPAGESWDSWFEEQGVTPDFIITREQPDDQIREDF

Download         Length: 231 bp

>AT225460 NZ_CP121151:c2355460-2355189 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References