Detailed information of TA system TA225457

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1125349..1125874
• Replicon: chromosome
• Accession: NZ_CP087392
• Organism: Pectobacterium parvum strain FN20211

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LOZ86_RS04990
• Protein ID: WP_039486183.1
• Coordinates: 1125349..1125633 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C6D956
• Locus tag: LOZ86_RS04995
• Protein ID: WP_005973616.1
• Coordinates: 1125623..1125874 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOZ86_RS04975 (LOZ86_04975)	1121628..1122768	+	1141	Protein_956	glycoside hydrolase family 88 protein	-
LOZ86_RS04980 (LOZ86_04980)	1123140..1123886	-	747	WP_039486185.1	SDR family oxidoreductase	-
LOZ86_RS04985 (LOZ86_04985)	1124599..1125165	+	567	WP_039513221.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
LOZ86_RS04990 (LOZ86_04990)	1125349..1125633	-	285	WP_039486183.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LOZ86_RS04995 (LOZ86_04995)	1125623..1125874	-	252	WP_005973616.1	prevent-host-death protein	Antitoxin
LOZ86_RS05000 (LOZ86_05000)	1126136..1128463	-	2328	WP_230242918.1	phage/plasmid primase, P4 family	-
LOZ86_RS05005 (LOZ86_05005)	1128474..1128815	-	342	WP_230242919.1	DUF5375 family protein	-
LOZ86_RS05010 (LOZ86_05010)	1128812..1129078	-	267	WP_161546823.1	hypothetical protein	-
LOZ86_RS05015 (LOZ86_05015)	1129075..1129269	-	195	WP_005973630.1	hypothetical protein	-
LOZ86_RS05020 (LOZ86_05020)	1129262..1129459	-	198	WP_039488123.1	host cell division inhibitor Icd-like protein	-
LOZ86_RS05025 (LOZ86_05025)	1129495..1129806	-	312	Protein_966	ash family protein	-
LOZ86_RS05030 (LOZ86_05030)	1129815..1130039	-	225	WP_015841426.1	hypothetical protein	-
LOZ86_RS05035 (LOZ86_05035)	1130036..1130260	-	225	WP_165707587.1	AlpA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11010.02 Da
• Isoelectric Point: 10.3917

>T225457 WP_039486183.1 NZ_CP087392:c1125633-1125349 [Pectobacterium parvum]
MSYKLEFEEHALKEFKKLGAPVREQFTKKLKEVLQNPHVPANRLHGMADCYKIKLRSAGYRLVYQVIKHEIVVLVLAVGK
RERSEVYKTAKDRL

Nucleotide

• Length: 285 bp

>T225457 NZ_CP121151:c1468396-1467071 [Escherichia coli]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9079.35 Da
• Isoelectric Point: 5.0807

>AT225457 WP_005973616.1 NZ_CP087392:c1125874-1125623 [Pectobacterium parvum]
MSVQPILANAAVSISDFKKSPNAALKEANGEPVAVLTNGRISGYYVSPETWEALADYQEDIELAKIARSRMKGKRVKVDL
DEL

Nucleotide

• Length: 252 bp

>AT225457 NZ_CP121151:c1468694-1468401 [Escherichia coli]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCATCCTGGGCGTAAAAATCAGCTTCTCCTCGGCAACCACCTCTTCAGAGAGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGGATTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0G4JQP6