Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 822986..823646 Replicon chromosome
Accession NZ_CP087392
Organism Pectobacterium parvum strain FN20211

Toxin (Protein)


Gene name cptA Uniprot ID A0A093S6F1
Locus tag LOZ86_RS03725 Protein ID WP_039487287.1
Coordinates 823233..823646 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A093SCR9
Locus tag LOZ86_RS03720 Protein ID WP_039487284.1
Coordinates 822986..823252 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOZ86_RS03700 (LOZ86_03700) 818842..819846 - 1005 WP_039487278.1 substrate-binding domain-containing protein -
LOZ86_RS03705 (LOZ86_03705) 819901..820509 - 609 WP_039487279.1 HD domain-containing protein -
LOZ86_RS03710 (LOZ86_03710) 820910..821557 + 648 WP_039487281.1 hemolysin III family protein -
LOZ86_RS03715 (LOZ86_03715) 821749..822750 - 1002 WP_039487282.1 tRNA-modifying protein YgfZ -
LOZ86_RS03720 (LOZ86_03720) 822986..823252 + 267 WP_039487284.1 FAD assembly factor SdhE Antitoxin
LOZ86_RS03725 (LOZ86_03725) 823233..823646 + 414 WP_039487287.1 protein YgfX Toxin
LOZ86_RS03730 (LOZ86_03730) 823715..824650 + 936 WP_039487289.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
LOZ86_RS03735 (LOZ86_03735) 824716..825039 - 324 WP_039487292.1 hypothetical protein -
LOZ86_RS03740 (LOZ86_03740) 825068..825586 - 519 WP_230243148.1 flavodoxin FldB -
LOZ86_RS03745 (LOZ86_03745) 825918..826304 - 387 WP_039282122.1 thioesterase family protein -
LOZ86_RS03750 (LOZ86_03750) 826529..827851 - 1323 WP_039487297.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16297.28 Da        Isoelectric Point: 10.6913

>T225456 WP_039487287.1 NZ_CP087392:823233-823646 [Pectobacterium parvum]
VAQWQCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQKNIKSRQGEIVLLSETTLNWRQQ
EWQIVKRPWLLKNGVLLSLRAVNGKDKQQLWLASDSMGDEEWRHLRQLLLQQKHWAR

Download         Length: 414 bp

>T225456 NZ_CP121151:1372525-1372923 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10489.90 Da        Isoelectric Point: 5.1392

>AT225456 WP_039487284.1 NZ_CP087392:822986-823252 [Pectobacterium parvum]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDTDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRIISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT225456 NZ_CP121151:1372298-1372525 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A093S6F1

Antitoxin

Source ID Structure
AlphaFold DB A0A093SCR9

References