Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 698995..699548 Replicon chromosome
Accession NZ_CP087392
Organism Pectobacterium parvum strain FN20211

Toxin (Protein)


Gene name relE Uniprot ID A0A6P1S0I2
Locus tag LOZ86_RS03065 Protein ID WP_039484573.1
Coordinates 699273..699548 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6P1S4N1
Locus tag LOZ86_RS03060 Protein ID WP_039484576.1
Coordinates 698995..699273 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOZ86_RS03035 (LOZ86_03035) 694377..695501 - 1125 WP_039484581.1 polysaccharide lyase -
LOZ86_RS03040 (LOZ86_03040) 696352..696603 + 252 WP_039484579.1 hypothetical protein -
LOZ86_RS03045 (LOZ86_03045) 697214..697456 + 243 WP_284145705.1 2Fe-2S iron-sulfur cluster-binding protein -
LOZ86_RS03050 (LOZ86_03050) 697469..698143 + 675 WP_039512666.1 hypothetical protein -
LOZ86_RS03055 (LOZ86_03055) 698629..698763 + 135 Protein_587 recombinase family protein -
LOZ86_RS03060 (LOZ86_03060) 698995..699273 + 279 WP_039484576.1 ribbon-helix-helix domain-containing protein Antitoxin
LOZ86_RS03065 (LOZ86_03065) 699273..699548 + 276 WP_039484573.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOZ86_RS03070 (LOZ86_03070) 699627..699725 + 99 Protein_590 IS6 family transposase -
LOZ86_RS03075 (LOZ86_03075) 699761..700039 - 279 Protein_591 Tn3 family transposase -
LOZ86_RS03080 (LOZ86_03080) 700040..700267 + 228 Protein_592 helix-turn-helix domain-containing protein -
LOZ86_RS03085 (LOZ86_03085) 700713..700793 - 81 Protein_593 IS1 family transposase -
LOZ86_RS03090 (LOZ86_03090) 702108..702683 + 576 WP_014916837.1 aminodeoxychorismate synthase component II -
LOZ86_RS03095 (LOZ86_03095) 702803..704029 + 1227 WP_039484568.1 aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 699761..699952 191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10682.30 Da        Isoelectric Point: 7.3183

>T225455 WP_039484573.1 NZ_CP087392:699273-699548 [Pectobacterium parvum]
MEIKWTSKALSDLAHLYEFLALANKSAAARAVQELTQAPAILLTNSRLGEQLFQFEPREIRRFLVGEYEVRHEIEKSVIY
VLRIWHAREDR

Download         Length: 276 bp

>T225455 NZ_CP121151:1007320-1007655 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10278.70 Da        Isoelectric Point: 5.6845

>AT225455 WP_039484576.1 NZ_CP087392:698995-699273 [Pectobacterium parvum]
MKNDTQVVTRVLTAHVPLPIADKVDQIAARLERSRGWIMKQALSAWIAQEEERDRLTQEALADVDAGRVIDHQAVQAWAD
SLGTDKPLPVPR

Download         Length: 279 bp

>AT225455 NZ_CP121151:1007072-1007320 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1S0I2

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1S4N1

References