Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 487187..487824 Replicon chromosome
Accession NZ_CP087391
Organism Bacillus amyloliquefaciens strain ZF57

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag LOZ87_RS02485 Protein ID WP_003156187.1
Coordinates 487474..487824 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID I2HMS5
Locus tag LOZ87_RS02480 Protein ID WP_003156188.1
Coordinates 487187..487468 (+) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOZ87_RS02460 (LOZ87_02460) 483552..484151 - 600 WP_020953896.1 rhomboid family intramembrane serine protease -
LOZ87_RS02465 (LOZ87_02465) 484244..484609 + 366 WP_007410229.1 holo-ACP synthase -
LOZ87_RS02470 (LOZ87_02470) 484774..485781 + 1008 WP_007410230.1 outer membrane lipoprotein carrier protein LolA -
LOZ87_RS02475 (LOZ87_02475) 485898..487067 + 1170 WP_039062648.1 alanine racemase -
LOZ87_RS02480 (LOZ87_02480) 487187..487468 + 282 WP_003156188.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
LOZ87_RS02485 (LOZ87_02485) 487474..487824 + 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
LOZ87_RS02490 (LOZ87_02490) 487942..488763 + 822 WP_003156182.1 STAS domain-containing protein -
LOZ87_RS02495 (LOZ87_02495) 488768..489133 + 366 WP_003156180.1 RsbT antagonist protein RsbS -
LOZ87_RS02500 (LOZ87_02500) 489136..489537 + 402 WP_003156178.1 anti-sigma regulatory factor -
LOZ87_RS02505 (LOZ87_02505) 489549..490556 + 1008 WP_007410233.1 PP2C family protein-serine/threonine phosphatase -
LOZ87_RS02510 (LOZ87_02510) 490620..490949 + 330 WP_003156176.1 anti-sigma factor antagonist RsbV -
LOZ87_RS02515 (LOZ87_02515) 490946..491428 + 483 WP_003156173.1 anti-sigma B factor RsbW -
LOZ87_RS02520 (LOZ87_02520) 491394..492182 + 789 WP_003156171.1 RNA polymerase sigma factor SigB -
LOZ87_RS02525 (LOZ87_02525) 492182..492784 + 603 WP_007410234.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-111)

Antitoxin

(12-45)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T225449 WP_003156187.1 NZ_CP087391:487474-487824 [Bacillus amyloliquefaciens]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

>T225449 NZ_CP121149:c4790160-4789849 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACCGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10562.92 Da        Isoelectric Point: 6.4706

>AT225449 WP_003156188.1 NZ_CP087391:487187-487468 [Bacillus amyloliquefaciens]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG

Download         Length: 282 bp

>AT225449 NZ_CP121149:c4789848-4789558 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8


Antitoxin

Source ID Structure
AlphaFold DB I2HMS5

References