Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 3207403..3208160 Replicon chromosome
Accession NZ_CP087390
Organism Enterobacter sp. AN-K1

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag LOC22_RS15265 Protein ID WP_196347929.1
Coordinates 3207403..3207786 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag LOC22_RS15270 Protein ID WP_196347930.1
Coordinates 3207822..3208160 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOC22_RS15240 (LOC22_15240) 3202602..3203003 + 402 WP_006809999.1 sigma factor-binding protein Crl -
LOC22_RS15245 (LOC22_15245) 3203136..3204188 - 1053 WP_017383128.1 phosphoporin PhoE -
LOC22_RS15250 (LOC22_15250) 3204494..3205597 + 1104 WP_015571369.1 glutamate 5-kinase -
LOC22_RS15255 (LOC22_15255) 3205609..3206862 + 1254 WP_047728882.1 glutamate-5-semialdehyde dehydrogenase -
LOC22_RS15265 (LOC22_15265) 3207403..3207786 - 384 WP_196347929.1 TA system toxin CbtA family protein Toxin
LOC22_RS15270 (LOC22_15270) 3207822..3208160 - 339 WP_196347930.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LOC22_RS15275 (LOC22_15275) 3208176..3208397 - 222 WP_196347931.1 DUF987 family protein -
LOC22_RS15280 (LOC22_15280) 3208394..3208894 - 501 WP_050555520.1 DNA repair protein RadC -
LOC22_RS15285 (LOC22_15285) 3208925..3209743 - 819 WP_196347933.1 DUF932 domain-containing protein -
LOC22_RS15290 (LOC22_15290) 3209842..3210423 - 582 WP_230239016.1 hypothetical protein -
LOC22_RS15295 (LOC22_15295) 3210806..3211699 - 894 WP_230239017.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(8-111)

Antitoxin

Antitoxin CbeA

(9-108)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14381.42 Da        Isoelectric Point: 8.6199

>T225446 WP_196347929.1 NZ_CP087390:c3207786-3207403 [Enterobacter sp. AN-K1]
MQISTAPTTEPVSSRLSPVEVWQILLKHLLAQHYGLTLNDTPFSDESTIREHINAGISLSNAVNFIVEKYELVRTDHSGF
TIMEQSPFISSIDILRARRATGLMKRHGYKSISNITTGHLLQERHLR

Download         Length: 384 bp

>T225446 NZ_CP121149:3895793-3896071 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAAGTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12474.18 Da        Isoelectric Point: 5.6016

>AT225446 WP_196347930.1 NZ_CP087390:c3208160-3207822 [Enterobacter sp. AN-K1]
MTKEPVQEHVWGLHSQTVPSFSARLVQEGRRLHFLADRATLLGTFSPEQSAALDAIFPALIRDMETALLSGKLDPREAKQ
YIYIRNGLTCESDTLGSCGYVYIVIYPQSEAS

Download         Length: 339 bp

>AT225446 NZ_CP121149:3895530-3895790 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References