Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2161845..2162461 Replicon chromosome
Accession NZ_CP087390
Organism Enterobacter sp. AN-K1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOC22_RS10370 Protein ID WP_023295637.1
Coordinates 2161845..2162216 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag LOC22_RS10375 Protein ID WP_015569912.1
Coordinates 2162219..2162461 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOC22_RS10355 (LOC22_10355) 2159345..2160247 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
LOC22_RS10360 (LOC22_10360) 2160244..2160879 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
LOC22_RS10365 (LOC22_10365) 2160876..2161805 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
LOC22_RS10370 (LOC22_10370) 2161845..2162216 - 372 WP_023295637.1 type II toxin-antitoxin system VapC family toxin Toxin
LOC22_RS10375 (LOC22_10375) 2162219..2162461 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
LOC22_RS10380 (LOC22_10380) 2162660..2163580 + 921 WP_017382675.1 alpha/beta hydrolase -
LOC22_RS10385 (LOC22_10385) 2163589..2164530 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
LOC22_RS10390 (LOC22_10390) 2164575..2165012 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
LOC22_RS10395 (LOC22_10395) 2165009..2165890 - 882 WP_003861949.1 virulence factor BrkB family protein -
LOC22_RS10400 (LOC22_10400) 2165884..2166483 - 600 WP_047055778.1 glucose-1-phosphatase -
LOC22_RS10405 (LOC22_10405) 2166602..2167402 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13751.90 Da        Isoelectric Point: 6.4882

>T225443 WP_023295637.1 NZ_CP087390:c2162216-2161845 [Enterobacter sp. AN-K1]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIVERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

>T225443 NZ_CP121149:2831120-2831227 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT225443 WP_015569912.1 NZ_CP087390:c2162461-2162219 [Enterobacter sp. AN-K1]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp

>AT225443 NZ_CP121149:c2831070-2831007 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References