225442

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1377642..1378299 Replicon chromosome
Accession NZ_CP087390
Organism Enterobacter sp. AN-K1

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag LOC22_RS06615 Protein ID WP_017382887.1
Coordinates 1377642..1378052 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag LOC22_RS06620 Protein ID WP_003863437.1
Coordinates 1378033..1378299 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOC22_RS06595 (LOC22_06595) 1373640..1375373 - 1734 WP_230239440.1 single-stranded-DNA-specific exonuclease RecJ -
LOC22_RS06600 (LOC22_06600) 1375379..1376092 - 714 WP_015571792.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LOC22_RS06605 (LOC22_06605) 1376121..1377017 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
LOC22_RS06610 (LOC22_06610) 1377119..1377640 + 522 WP_015571793.1 flavodoxin FldB -
LOC22_RS06615 (LOC22_06615) 1377642..1378052 - 411 WP_017382887.1 protein YgfX Toxin
LOC22_RS06620 (LOC22_06620) 1378033..1378299 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
LOC22_RS06625 (LOC22_06625) 1378594..1379574 + 981 WP_017692714.1 tRNA-modifying protein YgfZ -
LOC22_RS06630 (LOC22_06630) 1379686..1380345 - 660 WP_003863433.1 hemolysin III family protein -
LOC22_RS06635 (LOC22_06635) 1380612..1381343 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
LOC22_RS06640 (LOC22_06640) 1381460..1382893 + 1434 WP_045356743.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T225442 WP_017382887.1 NZ_CP087390:c1378052-1377642 [Enterobacter sp. AN-K1]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T225442 NZ_CP121149:2830585-2830692 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT225442 WP_003863437.1 NZ_CP087390:c1378299-1378033 [Enterobacter sp. AN-K1]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT225442 NZ_CP121149:c2830532-2830471 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References