Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4634727..4635322 Replicon chromosome
Accession NZ_CP087377
Organism Escherichia coli strain RIVM_C019217

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag LN359_RS22580 Protein ID WP_019842229.1
Coordinates 4634727..4635077 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag LN359_RS22585 Protein ID WP_001223213.1
Coordinates 4635071..4635322 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN359_RS22560 (4630057) 4630057..4631079 - 1023 WP_001550507.1 ABC transporter permease -
LN359_RS22565 (4631093) 4631093..4632595 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
LN359_RS22570 (4632727) 4632727..4633683 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LN359_RS22575 (4633993) 4633993..4634523 + 531 WP_000055075.1 inorganic diphosphatase -
LN359_RS22580 (4634727) 4634727..4635077 - 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
LN359_RS22585 (4635071) 4635071..4635322 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LN359_RS22590 (4635534) 4635534..4635875 - 342 WP_001550504.1 gamma-glutamylcyclotransferase -
LN359_RS22595 (4635878) 4635878..4639657 - 3780 WP_001550503.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T225415 WP_019842229.1 NZ_CP087377:c4635077-4634727 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T225415 NZ_CP121147:c2153992-2153885 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT225415 WP_001223213.1 NZ_CP087377:c4635322-4635071 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT225415 NZ_CP121147:2154040-2154106 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References