22541

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 883311..883788 Replicon chromosome
Accession NC_010079
Organism Staphylococcus aureus subsp. aureus USA300 TCH1516

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag USA300HOU_RS04315 Protein ID WP_000052078.1
Coordinates 883311..883499 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag USA300HOU_RS04320 Protein ID WP_001059690.1
Coordinates 883528..883788 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
USA300HOU_RS04285 879352..879822 + 471 WP_000824472.1 hypothetical protein -
USA300HOU_RS04290 880163..880849 + 687 WP_001548082.1 thermonuclease family protein -
USA300HOU_RS04295 881206..881406 + 201 WP_001059082.1 cold-shock protein -
USA300HOU_RS04300 881902..882120 - 219 WP_000005886.1 hypothetical protein -
USA300HOU_RS04305 882182..882466 - 285 WP_001004395.1 hypothetical protein -
USA300HOU_RS04310 882554..883123 - 570 WP_001106654.1 hypothetical protein -
USA300HOU_RS04315 883311..883499 - 189 WP_000052078.1 hypothetical protein Toxin
USA300HOU_RS04320 883528..883788 - 261 WP_001059690.1 hypothetical protein Antitoxin
USA300HOU_RS04325 884129..884332 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
USA300HOU_RS04330 884329..884565 - 237 WP_000368687.1 hypothetical protein -
USA300HOU_RS04335 884790..885371 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
USA300HOU_RS04340 885444..886061 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
USA300HOU_RS04345 886216..886710 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
USA300HOU_RS04350 887109..887531 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
USA300HOU_RS04355 887679..888395 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T22541 WP_000052078.1 NC_010079:c883499-883311 [Staphylococcus aureus subsp. aureus USA300_TCH1516]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T22541 NC_010079:c883499-883311 [Staphylococcus aureus subsp. aureus USA300_TCH1516]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT22541 WP_001059690.1 NC_010079:c883788-883528 [Staphylococcus aureus subsp. aureus USA300_TCH1516]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT22541 NC_010079:c883788-883528 [Staphylococcus aureus subsp. aureus USA300_TCH1516]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References