Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3095801..3096454 Replicon chromosome
Accession NZ_CP087351
Organism Acinetobacter baumannii strain DB003

Toxin (Protein)


Gene name cptA Uniprot ID B0V6V2
Locus tag LO008_RS15050 Protein ID WP_000931890.1
Coordinates 3095801..3096190 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag LO008_RS15055 Protein ID WP_001288210.1
Coordinates 3096197..3096454 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO008_RS15035 3090919..3093114 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
LO008_RS15040 3093302..3093868 - 567 WP_000651536.1 rhombosortase -
LO008_RS15045 3093946..3095031 - 1086 WP_000049106.1 hypothetical protein -
LO008_RS15050 3095801..3096190 - 390 WP_000931890.1 membrane protein Toxin
LO008_RS15055 3096197..3096454 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
LO008_RS15060 3096642..3097814 + 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
LO008_RS15065 3097864..3099354 - 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
LO008_RS15070 3099535..3099912 - 378 WP_001216380.1 50S ribosomal protein L17 -
LO008_RS15075 3099931..3100938 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T225385 WP_000931890.1 NZ_CP087351:c3096190-3095801 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T225385 NZ_CP121143:c3543452-3543168 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTTAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT225385 WP_001288210.1 NZ_CP087351:c3096454-3096197 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT225385 NZ_CP121143:c3543684-3543442 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCTGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1A4U0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References