Detailed information of TA system TA225383

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 450178..450831
• Replicon: chromosome
• Accession: NZ_CP087348
• Organism: Acinetobacter baumannii strain DB006

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LO006_RS02200
• Protein ID: WP_000607077.1
• Coordinates: 450442..450831 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: LO006_RS02195
• Protein ID: WP_001288210.1
• Coordinates: 450178..450435 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO006_RS02175	445694..446701	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
LO006_RS02180	446720..447097	+	378	WP_001216380.1	50S ribosomal protein L17	-
LO006_RS02185	447279..448769	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
LO006_RS02190	448818..449990	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
LO006_RS02195	450178..450435	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
LO006_RS02200	450442..450831	+	390	WP_000607077.1	membrane protein	Toxin
LO006_RS02205	451601..452686	+	1086	WP_000049106.1	hypothetical protein	-
LO006_RS02210	452764..453330	+	567	WP_000651538.1	rhombosortase	-
LO006_RS02215	453518..455713	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T225383 WP_000607077.1 NZ_CP087348:450442-450831 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T225383 NZ_CP121143:2817217-2817435 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT225383 WP_001288210.1 NZ_CP087348:450178-450435 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT225383 NZ_CP121143:2816816-2817190 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7