Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3325741..3326394 Replicon chromosome
Accession NZ_CP087340
Organism Acinetobacter baumannii strain DB008

Toxin (Protein)


Gene name cptA Uniprot ID A0A2S4T466
Locus tag LO011_RS16095 Protein ID WP_000607071.1
Coordinates 3325741..3326130 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID N9LG27
Locus tag LO011_RS16100 Protein ID WP_001288212.1
Coordinates 3326137..3326394 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO011_RS16080 3320859..3323054 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
LO011_RS16085 3323242..3323808 - 567 WP_000651536.1 rhombosortase -
LO011_RS16090 3323886..3324971 - 1086 WP_000049106.1 hypothetical protein -
LO011_RS16095 3325741..3326130 - 390 WP_000607071.1 membrane protein Toxin
LO011_RS16100 3326137..3326394 - 258 WP_001288212.1 succinate dehydrogenase assembly factor 2 Antitoxin
LO011_RS16105 3326582..3327754 + 1173 WP_258579410.1 acyl-CoA dehydrogenase family protein -
LO011_RS16110 3327801..3329291 - 1491 WP_005134653.1 NAD(P)/FAD-dependent oxidoreductase -
LO011_RS16115 3329473..3329850 - 378 WP_001216380.1 50S ribosomal protein L17 -
LO011_RS16120 3329869..3330876 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T225377 WP_000607071.1 NZ_CP087340:c3326130-3325741 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T225377 NZ_CP121141:c2504748-2504530 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10332.79 Da        Isoelectric Point: 4.6247

>AT225377 WP_001288212.1 NZ_CP087340:c3326394-3326137 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKAEPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT225377 NZ_CP121141:c2505149-2504775 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4T466

Antitoxin

Source ID Structure
AlphaFold DB N9LG27

References