Detailed information of TA system TA225376

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2595594..2596245
• Replicon: chromosome
• Accession: NZ_CP087340
• Organism: Acinetobacter baumannii strain DB008

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LO011_RS12685
• Protein ID: WP_000838150.1
• Coordinates: 2596063..2596245 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LO011_RS12680
• Protein ID: WP_000966686.1
• Coordinates: 2595594..2595998 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO011_RS12670	2590915..2594883	-	3969	WP_258579388.1	tape measure protein	-
LO011_RS12675	2594980..2595498	-	519	WP_001168930.1	DUF4468 domain-containing protein	-
LO011_RS12680	2595594..2595998	-	405	WP_000966686.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LO011_RS12685	2596063..2596245	-	183	WP_000838150.1	type II toxin-antitoxin system HicA family toxin	Toxin
LO011_RS12690	2596577..2597110	-	534	WP_001185622.1	hypothetical protein	-
LO011_RS12695	2597155..2598084	-	930	WP_057048502.1	phage tail tube protein	-
LO011_RS12700	2598192..2598404	-	213	WP_000121166.1	hypothetical protein	-
LO011_RS12705	2598406..2598804	-	399	WP_001132270.1	hypothetical protein	-
LO011_RS12710	2598806..2599174	-	369	WP_000539752.1	hypothetical protein	-
LO011_RS12715	2599146..2599550	-	405	WP_000248323.1	hypothetical protein	-
LO011_RS12720	2599559..2599927	-	369	WP_000524231.1	hypothetical protein	-
LO011_RS12725	2599929..2600318	-	390	WP_031958850.1	hypothetical protein	-
LO011_RS12730	2600323..2600988	-	666	WP_000767881.1	Ish1 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2571654..2622585	50931

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6622.83 Da
• Isoelectric Point: 10.7364

>T225376 WP_000838150.1 NZ_CP087340:c2596245-2596063 [Acinetobacter baumannii]
VKSLDLVKMIEADGWYLVRVKGSHHHFKHPTKGGLVTIPHPKKELPSGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T225376 NZ_CP121141:1892853-1893386 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTAGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14587.55 Da
• Isoelectric Point: 4.4082

>AT225376 WP_000966686.1 NZ_CP087340:c2595998-2595594 [Acinetobacter baumannii]
MLYPIAIERGNDTEAYGVTVPDIPGCFSAGDTLDEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDDADYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIHIIDENVGKGKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT225376 NZ_CP121141:1892576-1892842 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA