Detailed information of TA system TA225375

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1909085..1910721
• Replicon: chromosome
• Accession: NZ_CP087340
• Organism: Acinetobacter baumannii strain DB008

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A1E3M7C1
• Locus tag: LO011_RS09290
• Protein ID: WP_000737056.1
• Coordinates: 1909390..1910721 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LO011_RS09285
• Protein ID: WP_001101308.1
• Coordinates: 1909085..1909393 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO011_RS09260	1904880..1905167	-	288	Protein_1804	GNAT family N-acetyltransferase	-
LO011_RS09265	1905315..1905830	-	516	WP_000914805.1	hypothetical protein	-
LO011_RS09270	1905872..1906954	-	1083	WP_001095788.1	XRE family transcriptional regulator	-
LO011_RS09275	1906972..1907592	-	621	WP_000658761.1	hypothetical protein	-
LO011_RS09280	1907808..1908359	-	552	WP_005135235.1	TetR/AcrR family transcriptional regulator	-
LO011_RS09285	1909085..1909393	-	309	WP_001101308.1	helix-turn-helix domain-containing protein	Antitoxin
LO011_RS09290	1909390..1910721	-	1332	WP_000737056.1	HipA domain-containing protein	Toxin
LO011_RS09295	1911017..1911457	+	441	WP_000193135.1	HD domain-containing protein	-
LO011_RS09300	1911492..1912136	-	645	WP_000817301.1	hypothetical protein	-
LO011_RS09305	1912148..1913119	-	972	WP_109104914.1	5'/3'-nucleotidase SurE	-
LO011_RS09310	1913246..1913773	-	528	Protein_1814	hypothetical protein	-
LO011_RS09315	1913814..1915022	-	1209	WP_000343018.1	IS256-like element ISAba26 family transposase	-
LO011_RS09320	1915098..1915436	-	339	Protein_1816	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1913814..1915022	1208

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51189.16 Da
• Isoelectric Point: 4.7456

>T225375 WP_000737056.1 NZ_CP087340:c1910721-1909390 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNNRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T225375 NZ_CP121141:1778513-1778797 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTTAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11626.55 Da
• Isoelectric Point: 9.9701

>AT225375 WP_001101308.1 NZ_CP087340:c1909393-1909085 [Acinetobacter baumannii]
MNVKNQPQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT225375 NZ_CP121141:1778281-1778523 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCTGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: A0A1E3M7C1