Detailed information of TA system TA225372

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2911081..2911760
• Replicon: chromosome
• Accession: NZ_CP087335
• Organism: Acinetobacter baumannii strain DB053

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: LO010_RS13985
• Protein ID: WP_000838146.1
• Coordinates: 2911578..2911760 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: LO010_RS13980
• Protein ID: WP_000966688.1
• Coordinates: 2911081..2911485 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO010_RS13970	2910036..2910299	-	264	WP_001275792.1	hypothetical protein	-
LO010_RS13975	2910301..2910981	-	681	WP_000721572.1	hypothetical protein	-
LO010_RS13980	2911081..2911485	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LO010_RS13985	2911578..2911760	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
LO010_RS13990	2912086..2912601	-	516	WP_002132544.1	hypothetical protein	-
LO010_RS13995	2912671..2913588	-	918	WP_000094250.1	phage tail tube protein	-
LO010_RS14000	2913641..2914612	-	972	WP_025467109.1	hypothetical protein	-
LO010_RS14005	2914612..2914965	-	354	WP_002055486.1	hypothetical protein	-
LO010_RS14010	2915062..2915583	-	522	WP_002055493.1	SH3 domain-containing protein	-
LO010_RS14015	2915692..2915910	-	219	WP_002132566.1	hypothetical protein	-
LO010_RS14020	2915912..2916310	-	399	WP_001251837.1	phage tail terminator-like protein	-
LO010_RS14025	2916312..2916680	-	369	WP_032001521.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2892325..2947797	55472

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T225372 WP_000838146.1 NZ_CP087335:c2911760-2911578 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T225372 NZ_CP121141:c1018904-1018419 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATGCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT225372 WP_000966688.1 NZ_CP087335:c2911485-2911081 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT225372 NZ_CP121141:c1019158-1018892 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6