Detailed information of TA system TA225371

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1964916..1966552
• Replicon: chromosome
• Accession: NZ_CP087335
• Organism: Acinetobacter baumannii strain DB053

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2S4T3J5
• Locus tag: LO010_RS09335
• Protein ID: WP_000737053.1
• Coordinates: 1964916..1966247 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LO010_RS09340
• Protein ID: WP_001101310.1
• Coordinates: 1966244..1966552 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO010_RS09315	1961226..1962389	+	1164	WP_001044482.1	hypothetical protein	-
LO010_RS09320	1962516..1963487	+	972	WP_086262266.1	5'/3'-nucleotidase SurE	-
LO010_RS09325	1963499..1964143	+	645	WP_000817308.1	hypothetical protein	-
LO010_RS09330	1964180..1964620	-	441	WP_000193125.1	HD domain-containing protein	-
LO010_RS09335	1964916..1966247	+	1332	WP_000737053.1	HipA domain-containing protein	Toxin
LO010_RS09340	1966244..1966552	+	309	WP_001101310.1	helix-turn-helix domain-containing protein	Antitoxin
LO010_RS09345	1967276..1967842	+	567	WP_002057028.1	TetR/AcrR family transcriptional regulator	-
LO010_RS09350	1967940..1970750	-	2811	WP_000920188.1	AAA family ATPase	-
LO010_RS09355	1970754..1971257	-	504	WP_000499424.1	hypothetical protein	-
LO010_RS09360	1971364..1971456	-	93	Protein_1821	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51189.29 Da
• Isoelectric Point: 4.9147

>T225371 WP_000737053.1 NZ_CP087335:1964916-1966247 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPDSTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T225371 NZ_CP121141:c892056-891688 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11630.54 Da
• Isoelectric Point: 9.9701

>AT225371 WP_001101310.1 NZ_CP087335:1966244-1966552 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT225371 NZ_CP121141:c892274-892053 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A2S4T3J5