Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-UPF0150
Location 1327227..1327657 Replicon chromosome
Accession NC_010003
Organism Petrotoga mobilis SJ95

Toxin (Protein)


Gene name hicA Uniprot ID A0A2K1NFS5
Locus tag PMOB_RS06360 Protein ID WP_012209056.1
Coordinates 1327227..1327451 (-) Length 75 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2K1NFP2
Locus tag PMOB_RS06365 Protein ID WP_041534088.1
Coordinates 1327451..1327657 (-) Length 69 a.a.

Genomic Context

PMOB_RS06370PMOB_RS06375PMOB_RS10815PMOB_RS06350PMOB_RS06355PMOB_RS06360PMOB_RS06365
Location: 1327839..1329587 (1749 bp)
Type: Others
Protein ID: WP_012209058.1
Location: 1330175..1332406 (2232 bp)
Type: Others
Protein ID: WP_012209059.1
Location: 1332387..1332557 (171 bp)
Type: Others
Protein ID: Protein_1264
Location: 1322346..1324787 (2442 bp)
Type: Others
Protein ID: WP_012209054.1
Location: 1324817..1326754 (1938 bp)
Type: Others
Protein ID: WP_012209055.1
Location: 1327227..1327451 (225 bp)
Type: Toxin
Protein ID: WP_012209056.1
Location: 1327451..1327657 (207 bp)
Type: Antitoxin
Protein ID: WP_041534088.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PMOB_RS063501322346..1324787-2442WP_012209054.1DNA gyrase subunit A-
PMOB_RS063551324817..1326754-1938WP_012209055.1methionine--tRNA ligase-
PMOB_RS063601327227..1327451-225WP_012209056.1type II toxin-antitoxin system HicA family toxinToxin
PMOB_RS063651327451..1327657-207WP_041534088.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
PMOB_RS063701327839..1329587+1749WP_012209058.1proline--tRNA ligase-
PMOB_RS063751330175..1332406+2232WP_012209059.1hypothetical protein-
PMOB_RS108151332387..1332557+171Protein_1264ATP-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(9-64)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-58)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8288.80 Da        Isoelectric Point: 11.2132

>T22537 WP_012209056.1 NC_010003:c1327451-1327227 [Petrotoga mobilis SJ95]
MEKLPLLSGREVVKVFERLGWEVARQRGSHIILVKGKHIATLSVPDHREVARGTLRSLIARAGITVEEFLSAMK

Download         Length: 225 bp

>T22537 NC_010003:c1327451-1327227 [Petrotoga mobilis SJ95]
ATGGAAAAACTTCCACTTTTAAGCGGGCGTGAAGTTGTAAAAGTTTTTGAACGTCTTGGATGGGAAGTAGCAAGGCAACG
AGGTAGTCATATTATTCTTGTGAAGGGGAAACACATTGCCACACTATCTGTCCCTGATCATCGTGAAGTTGCAAGAGGAA
CTTTGAGGTCACTCATTGCTCGTGCTGGTATAACAGTTGAAGAGTTTTTGTCTGCGATGAAATGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7586.78 Da        Isoelectric Point: 4.2702

>AT22537 WP_041534088.1 NC_010003:c1327657-1327451 [Petrotoga mobilis SJ95]
MKFIVTIDRDEDGMFVVECPSIPGCVSQGKTEQEAIENIKDAIKQCLEVRAERGMPLTVSMREVEVSV

Download         Length: 207 bp

>AT22537 NC_010003:c1327657-1327451 [Petrotoga mobilis SJ95]
ATGAAATTTATCGTAACAATTGATCGGGATGAGGATGGCATGTTCGTAGTAGAATGTCCTTCTATCCCTGGATGTGTAAG
TCAAGGAAAAACCGAACAAGAAGCGATTGAGAATATCAAAGATGCAATAAAGCAGTGCCTTGAGGTGCGAGCCGAAAGAG
GTATGCCTCTCACCGTTAGTATGCGTGAAGTAGAGGTATCGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2K1NFS5

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2K1NFP2

References