Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-UPF0150
Location 1327227..1327657 Replicon chromosome
Accession NC_010003
Organism Petrotoga mobilis SJ95

Toxin (Protein)


Gene name hicA Uniprot ID A0A2K1NFS5
Locus tag PMOB_RS06360 Protein ID WP_012209056.1
Coordinates 1327227..1327451 (-) Length 75 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2K1NFP2
Locus tag PMOB_RS06365 Protein ID WP_041534088.1
Coordinates 1327451..1327657 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMOB_RS06350 1322346..1324787 - 2442 WP_012209054.1 DNA gyrase subunit A -
PMOB_RS06355 1324817..1326754 - 1938 WP_012209055.1 methionine--tRNA ligase -
PMOB_RS06360 1327227..1327451 - 225 WP_012209056.1 type II toxin-antitoxin system HicA family toxin Toxin
PMOB_RS06365 1327451..1327657 - 207 WP_041534088.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PMOB_RS06370 1327839..1329587 + 1749 WP_012209058.1 proline--tRNA ligase -
PMOB_RS06375 1330175..1332406 + 2232 WP_012209059.1 hypothetical protein -
PMOB_RS10815 1332387..1332557 + 171 Protein_1264 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(9-64)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-58)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8288.80 Da        Isoelectric Point: 11.2132

>T22537 WP_012209056.1 NC_010003:c1327451-1327227 [Petrotoga mobilis SJ95]
MEKLPLLSGREVVKVFERLGWEVARQRGSHIILVKGKHIATLSVPDHREVARGTLRSLIARAGITVEEFLSAMK

Download         Length: 225 bp

>T22537 NC_010003:c1327451-1327227 [Petrotoga mobilis SJ95]
ATGGAAAAACTTCCACTTTTAAGCGGGCGTGAAGTTGTAAAAGTTTTTGAACGTCTTGGATGGGAAGTAGCAAGGCAACG
AGGTAGTCATATTATTCTTGTGAAGGGGAAACACATTGCCACACTATCTGTCCCTGATCATCGTGAAGTTGCAAGAGGAA
CTTTGAGGTCACTCATTGCTCGTGCTGGTATAACAGTTGAAGAGTTTTTGTCTGCGATGAAATGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7586.78 Da        Isoelectric Point: 4.2702

>AT22537 WP_041534088.1 NC_010003:c1327657-1327451 [Petrotoga mobilis SJ95]
MKFIVTIDRDEDGMFVVECPSIPGCVSQGKTEQEAIENIKDAIKQCLEVRAERGMPLTVSMREVEVSV

Download         Length: 207 bp

>AT22537 NC_010003:c1327657-1327451 [Petrotoga mobilis SJ95]
ATGAAATTTATCGTAACAATTGATCGGGATGAGGATGGCATGTTCGTAGTAGAATGTCCTTCTATCCCTGGATGTGTAAG
TCAAGGAAAAACCGAACAAGAAGCGATTGAGAATATCAAAGATGCAATAAAGCAGTGCCTTGAGGTGCGAGCCGAAAGAG
GTATGCCTCTCACCGTTAGTATGCGTGAAGTAGAGGTATCGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1NFS5

Antitoxin

Source ID Structure
AlphaFold DB A0A2K1NFP2

References