Detailed information of TA system TA225369

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2892055..2892734
• Replicon: chromosome
• Accession: NZ_CP087331
• Organism: Acinetobacter baumannii strain LMG994

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LO004_RS13845
• Protein ID: WP_000838145.1
• Coordinates: 2892552..2892734 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: LO004_RS13840
• Protein ID: WP_000966688.1
• Coordinates: 2892055..2892459 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO004_RS13805	2887549..2888469	-	921	WP_000202272.1	KilA-N domain-containing protein	-
LO004_RS13810	2888549..2888710	-	162	WP_164463375.1	hypothetical protein	-
LO004_RS13815	2888835..2889353	+	519	WP_001293807.1	Arc family DNA-binding protein	-
LO004_RS13820	2889396..2889662	-	267	WP_223235868.1	hypothetical protein	-
LO004_RS13825	2889675..2890607	+	933	WP_001043692.1	IS5-like element ISAba13 family transposase	-
LO004_RS13830	2890630..2891367	-	738	WP_223233742.1	hypothetical protein	-
LO004_RS13835	2891432..2891956	-	525	WP_110294140.1	DUF4468 domain-containing protein	-
LO004_RS13840	2892055..2892459	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LO004_RS13845	2892552..2892734	-	183	WP_000838145.1	type II toxin-antitoxin system HicA family toxin	Toxin
LO004_RS13850	2893062..2893577	-	516	WP_024616020.1	hypothetical protein	-
LO004_RS13855	2893648..2894565	-	918	WP_000094253.1	phage tail tube protein	-
LO004_RS13860	2894618..2895973	-	1356	WP_000002416.1	hypothetical protein	-
LO004_RS13865	2895973..2896326	-	354	WP_000064599.1	hypothetical protein	-
LO004_RS13870	2896420..2896638	-	219	WP_001277687.1	hypothetical protein	-
LO004_RS13875	2896640..2897038	-	399	WP_001251850.1	phage tail terminator-like protein	-
LO004_RS13880	2897040..2897408	-	369	WP_002055488.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2867823..2925268	57445
	-	flank	IS/Tn	-	-	2889675..2890607	932

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6729.85 Da
• Isoelectric Point: 10.5523

>T225369 WP_000838145.1 NZ_CP087331:c2892734-2892552 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSFLKQAGLN

Nucleotide

• Length: 183 bp

>T225369 NZ_CP121141:c421911-421501 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGATGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT225369 WP_000966688.1 NZ_CP087331:c2892459-2892055 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT225369 NZ_CP121141:c422158-421892 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: N9L2H6