Detailed information of TA system TA225368

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 638761..639414
• Replicon: chromosome
• Accession: NZ_CP087331
• Organism: Acinetobacter baumannii strain LMG994

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LO004_RS03120
• Protein ID: WP_000607072.1
• Coordinates: 639025..639414 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: LO004_RS03115
• Protein ID: WP_001288210.1
• Coordinates: 638761..639018 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO004_RS03095	634277..635284	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
LO004_RS03100	635303..635680	+	378	WP_001216380.1	50S ribosomal protein L17	-
LO004_RS03105	635862..637352	+	1491	WP_000415138.1	NAD(P)/FAD-dependent oxidoreductase	-
LO004_RS03110	637401..638573	-	1173	WP_001190549.1	acyl-CoA dehydrogenase family protein	-
LO004_RS03115	638761..639018	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
LO004_RS03120	639025..639414	+	390	WP_000607072.1	membrane protein	Toxin
LO004_RS03125	640184..641269	+	1086	WP_000049106.1	hypothetical protein	-
LO004_RS03130	641347..641913	+	567	WP_000651536.1	rhombosortase	-
LO004_RS03135	642101..644296	+	2196	WP_001158907.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15663.97 Da
• Isoelectric Point: 10.3890

>T225368 WP_000607072.1 NZ_CP087331:639025-639414 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLVDWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T225368 NZ_CP121140:c100693-100211 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT225368 WP_001288210.1 NZ_CP087331:638761-639018 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT225368 NZ_CP121140:c100947-100681 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7