Detailed information of TA system TA225364

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1893063..1894699
• Replicon: chromosome
• Accession: NZ_CP087328
• Organism: Acinetobacter baumannii strain OC074

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LOZ98_RS09400
• Protein ID: WP_114225260.1
• Coordinates: 1893063..1894394 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LOZ98_RS09405
• Protein ID: WP_001101310.1
• Coordinates: 1894391..1894699 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOZ98_RS09380	1888470..1889237	+	768	WP_114225127.1	NUDIX domain-containing protein	-
LOZ98_RS09385	1889311..1890705	+	1395	WP_114225128.1	methylenetetrahydrofolate reductase C-terminal domain-containing protein	-
LOZ98_RS09390	1891266..1892198	-	933	WP_001043692.1	IS5-like element ISAba13 family transposase	-
LOZ98_RS09395	1892328..1892768	-	441	WP_032018238.1	HD domain-containing protein	-
LOZ98_RS09400	1893063..1894394	+	1332	WP_114225260.1	HipA domain-containing protein	Toxin
LOZ98_RS09405	1894391..1894699	+	309	WP_001101310.1	helix-turn-helix domain-containing protein	Antitoxin
LOZ98_RS09410	1895538..1896188	+	651	WP_230283172.1	IS3 family transposase	-
LOZ98_RS09415	1896420..1897252	-	833	Protein_1831	SDR family NAD(P)-dependent oxidoreductase	-
LOZ98_RS09420	1897298..1897804	-	507	Protein_1832	SDR family NAD(P)-dependent oxidoreductase	-
LOZ98_RS09425	1897804..1898208	+	405	Protein_1833	multidrug efflux RND transporter periplasmic adaptor subunit AdeA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	1891266..1896188	4922

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51188.22 Da
• Isoelectric Point: 4.8490

>T225364 WP_114225260.1 NZ_CP087328:1893063-1894394 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESNTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFVCEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T225364 NZ_CP121139:c4672672-4672325 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAATCGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11630.54 Da
• Isoelectric Point: 9.9701

>AT225364 WP_001101310.1 NZ_CP087328:1894391-1894699 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT225364 NZ_CP121139:c4672325-4672026 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA