Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 459736..460389 Replicon chromosome
Accession NZ_CP087328
Organism Acinetobacter baumannii strain OC074

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J8TGE7
Locus tag LOZ98_RS02285 Protein ID WP_024437032.1
Coordinates 460000..460389 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag LOZ98_RS02280 Protein ID WP_001288210.1
Coordinates 459736..459993 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOZ98_RS02260 455252..456259 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
LOZ98_RS02265 456278..456655 + 378 WP_001216380.1 50S ribosomal protein L17 -
LOZ98_RS02270 456837..458327 + 1491 WP_000415132.1 NAD(P)/FAD-dependent oxidoreductase -
LOZ98_RS02275 458376..459548 - 1173 WP_017725189.1 acyl-CoA dehydrogenase family protein -
LOZ98_RS02280 459736..459993 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
LOZ98_RS02285 460000..460389 + 390 WP_024437032.1 membrane protein Toxin
LOZ98_RS02290 461159..462244 + 1086 WP_000049106.1 hypothetical protein -
LOZ98_RS02295 462322..462888 + 567 WP_000651536.1 rhombosortase -
LOZ98_RS02300 463076..463582 + 507 Protein_446 hypothetical protein -
LOZ98_RS02305 463637..464845 + 1209 WP_000343018.1 IS256-like element ISAba26 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 463637..464845 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15584.82 Da        Isoelectric Point: 10.3889

>T225363 WP_024437032.1 NZ_CP087328:460000-460389 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAALFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYQSQNTV
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T225363 NZ_CP121139:c4227770-4227360 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGATGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT225363 WP_001288210.1 NZ_CP087328:459736-459993 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT225363 NZ_CP121139:c4228017-4227751 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TGE7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References