Detailed information of TA system TA225359

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3002253..3002931
• Replicon: chromosome
• Accession: NZ_CP087325
• Organism: Acinetobacter baumannii strain OC073

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LO013_RS14685
• Protein ID: WP_000009390.1
• Coordinates: 3002253..3002432 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A009Q2Y3
• Locus tag: LO013_RS14690
• Protein ID: WP_032058837.1
• Coordinates: 3002518..3002931 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO013_RS14665	2998059..2998919	-	861	WP_196085344.1	GPO family capsid scaffolding protein	-
LO013_RS14670	2999098..3000876	+	1779	WP_196085343.1	terminase family protein	-
LO013_RS14675	3000873..3001919	+	1047	WP_254231395.1	phage portal protein	-
LO013_RS14680	3001930..3002145	+	216	WP_227552920.1	hypothetical protein	-
LO013_RS14685	3002253..3002432	+	180	WP_000009390.1	type II toxin-antitoxin system HicA family toxin	Toxin
LO013_RS14690	3002518..3002931	+	414	WP_032058837.1	antitoxin	Antitoxin
LO013_RS14715	3004900..3005964	-	1065	WP_001278262.1	quinolinate synthase NadA	-
LO013_RS14720	3006111..3007331	-	1221	WP_000268125.1	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2958246..3002931	44685

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (16-78)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6799.11 Da
• Isoelectric Point: 11.1422

>T225359 WP_000009390.1 NZ_CP087325:3002253-3002432 [Acinetobacter baumannii]
MSFNEFKRWLIAQGVIFVRKGKGSHMIIEFNGKKTVFPNHGKKEIPEGTRLKIKKDLGL

Nucleotide

• Length: 180 bp

>T225359 NZ_CP121139:381998-382531 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTAGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15334.70 Da
• Isoelectric Point: 6.2451

>AT225359 WP_032058837.1 NZ_CP087325:3002518-3002931 [Acinetobacter baumannii]
MKCYVSIHREGEAFIVSSSELPELNSVGYTLEEALSEALDGIETVFEIYMDERKAIPLPSKGKKGEYAVHLPVRVAAKVR
LYNEMISQNVTKAELARRLGWLQKQADRLLSLKHSTKLESIESAFQALGKDLDIVIA

Nucleotide

• Length: 414 bp

>AT225359 NZ_CP121139:381721-381987 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A009Q2Y3