Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 541968..542621 Replicon chromosome
Accession NZ_CP087325
Organism Acinetobacter baumannii strain OC073

Toxin (Protein)


Gene name cptA Uniprot ID A0A829RKD8
Locus tag LO013_RS02665 Protein ID WP_002125600.1
Coordinates 542232..542621 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag LO013_RS02660 Protein ID WP_001288210.1
Coordinates 541968..542225 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO013_RS02640 537228..537605 + 378 WP_001216380.1 50S ribosomal protein L17 -
LO013_RS02645 537787..539277 + 1491 WP_002125480.1 NAD(P)/FAD-dependent oxidoreductase -
LO013_RS02650 539405..540559 + 1155 WP_004738527.1 IS4 family transposase -
LO013_RS02655 540608..541780 - 1173 WP_002125555.1 acyl-CoA dehydrogenase family protein -
LO013_RS02660 541968..542225 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
LO013_RS02665 542232..542621 + 390 WP_002125600.1 hypothetical protein Toxin
LO013_RS02670 543391..544476 + 1086 WP_000049106.1 hypothetical protein -
LO013_RS02675 544554..545120 + 567 WP_000651536.1 rhombosortase -
LO013_RS02680 545308..547503 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 539405..540559 1154


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15662.98 Da        Isoelectric Point: 10.4623

>T225358 WP_002125600.1 NZ_CP087325:542232-542621 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKIWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T225358 NZ_CP121139:267658-267942 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTTAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT225358 WP_001288210.1 NZ_CP087325:541968-542225 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT225358 NZ_CP121139:267426-267668 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCTGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829RKD8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References