Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 419110..419738 Replicon chromosome
Accession NZ_CP087325
Organism Acinetobacter baumannii strain OC073

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LO013_RS01985 Protein ID WP_004833671.1
Coordinates 419110..419511 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A158LZG4
Locus tag LO013_RS01990 Protein ID WP_002125542.1
Coordinates 419511..419738 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO013_RS01960 414791..415678 + 888 WP_004833668.1 metal-dependent hydrolase -
LO013_RS01965 415809..416399 + 591 WP_000846931.1 LemA family protein -
LO013_RS01970 416421..417503 + 1083 WP_001246384.1 TPM domain-containing protein -
LO013_RS01975 417497..418057 + 561 WP_002125582.1 TPM domain-containing protein -
LO013_RS01980 418398..418838 + 441 WP_258578340.1 pilin -
LO013_RS01985 419110..419511 - 402 WP_004833671.1 type II toxin-antitoxin system VapC family toxin Toxin
LO013_RS01990 419511..419738 - 228 WP_002125542.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LO013_RS01995 419891..421519 + 1629 WP_025467250.1 O-antigen ligase family protein -
LO013_RS02000 421562..422026 - 465 WP_000678123.1 bacterioferritin -
LO013_RS02005 422271..422465 - 195 WP_000289091.1 bacterioferritin-associated ferredoxin -
LO013_RS02010 422675..423058 - 384 WP_000090000.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15100.37 Da        Isoelectric Point: 7.2756

>T225357 WP_004833671.1 NZ_CP087325:c419511-419110 [Acinetobacter baumannii]
MLRYMLDTNIVIYTIKNKPPEVKVRFNAVATQLCVSSITVAELIYGAENSQNPIKNLRVVEDFLSRLQILDYTPEAAAQY
GMIKADLRRKGTLISDNDTHIAAHARSHGLILVTNNTKEFQRVEALQLENWVE

Download         Length: 402 bp

>T225357 NZ_CP121139:109559-110476 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAGTCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8706.86 Da        Isoelectric Point: 4.7361

>AT225357 WP_002125542.1 NZ_CP087325:c419738-419511 [Acinetobacter baumannii]
MITSVFTNNRSQAVRLPAIFRFPKETQKVFVRVVGVERVICPVEHIWDSFFDDAQLTVSDDFERGEQIAAERESF

Download         Length: 228 bp

>AT225357 NZ_CP121139:108795-109553 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAGCCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A158LZG4

References