Detailed information of TA system TA225351

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3505140..3505793
• Replicon: chromosome
• Accession: NZ_CP087321
• Organism: Acinetobacter baumannii strain OC043

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LO002_RS16900
• Protein ID: WP_000607077.1
• Coordinates: 3505140..3505529 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: LO002_RS16905
• Protein ID: WP_001288210.1
• Coordinates: 3505536..3505793 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO002_RS16885	3500258..3502453	-	2196	WP_001158906.1	TRAP transporter large permease subunit	-
LO002_RS16890	3502641..3503207	-	567	WP_000651538.1	rhombosortase	-
LO002_RS16895	3503285..3504370	-	1086	WP_000049106.1	hypothetical protein	-
LO002_RS16900	3505140..3505529	-	390	WP_000607077.1	membrane protein	Toxin
LO002_RS16905	3505536..3505793	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
LO002_RS16910	3505981..3507153	+	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
LO002_RS16915	3507202..3508692	-	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
LO002_RS16920	3508874..3509251	-	378	WP_001216380.1	50S ribosomal protein L17	-
LO002_RS16925	3509270..3510277	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T225351 WP_000607077.1 NZ_CP087321:c3505529-3505140 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T225351 NZ_CP121137:c4025409-4025026 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCATCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT225351 WP_001288210.1 NZ_CP087321:c3505793-3505536 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT225351 NZ_CP121137:c4025651-4025409 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7