225350

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 29966..30491 Replicon plasmid p1OC064
Accession NZ_CP087319
Organism Acinetobacter baumannii strain OC064

Toxin (Protein)


Gene name relE Uniprot ID A0A7U3Y3F8
Locus tag LO012_RS20215 Protein ID WP_000221350.1
Coordinates 30204..30491 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R9B9T8
Locus tag LO012_RS20210 Protein ID WP_000192612.1
Coordinates 29966..30214 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO012_RS20180 26524..26832 + 309 WP_000796997.1 DUF3387 domain-containing protein -
LO012_RS20185 27037..27984 - 948 WP_000845976.1 replication initiation protein RepM -
LO012_RS20190 28409..29038 + 630 WP_000584713.1 AAA family ATPase -
LO012_RS20195 29035..29271 + 237 WP_000592589.1 hypothetical protein -
LO012_RS20200 29387..29455 + 69 Protein_32 helix-turn-helix domain-containing protein -
LO012_RS20205 29538..29963 + 426 WP_001083446.1 hypothetical protein -
LO012_RS20210 29966..30214 + 249 WP_000192612.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LO012_RS20215 30204..30491 + 288 WP_000221350.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LO012_RS20220 30763..32012 + 1250 Protein_36 IS3 family transposase -
LO012_RS20225 32649..32768 + 120 Protein_37 recombinase family protein -
LO012_RS20230 32832..33536 + 705 WP_001067856.1 IS6-like element IS26 family transposase -
LO012_RS20235 33588..33872 - 285 Protein_39 AraC family ligand binding domain-containing protein -
LO012_RS20240 34046..34752 - 707 Protein_40 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-Ia / blaOXA-58 - 1..36555 36555


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11054.85 Da        Isoelectric Point: 10.0443

>T225350 WP_000221350.1 NZ_CP087319:30204-30491 [Acinetobacter baumannii]
MTYKLDFLEEALAEWNKLNPSIKQPLKKKLIKVLENPHIPKNKLSGHPNRYKIKLRSVGYRLVYEVIDDEVVVIVIAVGR
RENNAVYDEANSRHS

Download         Length: 288 bp

>T225350 NZ_CP121137:c3701542-3700625 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAGTCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9246.72 Da        Isoelectric Point: 5.0491

>AT225350 WP_000192612.1 NZ_CP087319:29966-30214 [Acinetobacter baumannii]
MTQLIHARMTASITELKKSPMDTVLAGKGEPVAILNRNTPAFYCVPADLYETMMEQLEDLELNKIADARANQKRIRVNID
DL

Download         Length: 249 bp

>AT225350 NZ_CP121137:c3702306-3701548 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAGCCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3Y3F8

Antitoxin

Source ID Structure
AlphaFold DB R9B9T8

References