Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 15363..15888 Replicon plasmid p2OC064
Accession NZ_CP087318
Organism Acinetobacter baumannii strain OC064

Toxin (Protein)


Gene name relE Uniprot ID A0A7U3Y3F8
Locus tag LO012_RS19895 Protein ID WP_000221350.1
Coordinates 15601..15888 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R9B9T8
Locus tag LO012_RS19890 Protein ID WP_000192612.1
Coordinates 15363..15611 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO012_RS19860 11921..12229 + 309 WP_000796997.1 DUF3387 domain-containing protein -
LO012_RS19865 12434..13381 - 948 WP_000845976.1 replication initiation protein RepM -
LO012_RS19870 13806..14435 + 630 WP_000584713.1 AAA family ATPase -
LO012_RS19875 14432..14668 + 237 WP_000592589.1 hypothetical protein -
LO012_RS19880 14784..14852 + 69 Protein_13 helix-turn-helix domain-containing protein -
LO012_RS19885 14935..15360 + 426 WP_001083446.1 hypothetical protein -
LO012_RS19890 15363..15611 + 249 WP_000192612.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LO012_RS19895 15601..15888 + 288 WP_000221350.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LO012_RS19900 16160..17409 + 1250 Protein_17 IS3 family transposase -
LO012_RS19905 18046..18165 + 120 Protein_18 recombinase family protein -
LO012_RS19910 18229..18933 + 705 WP_001067856.1 IS6-like element IS26 family transposase -
LO012_RS19915 18985..19269 - 285 Protein_20 AraC family ligand binding domain-containing protein -
LO012_RS19920 19443..20149 - 707 Protein_21 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-58 / aph(3')-Ia - 1..37306 37306


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11054.85 Da        Isoelectric Point: 10.0443

>T225347 WP_000221350.1 NZ_CP087318:15601-15888 [Acinetobacter baumannii]
MTYKLDFLEEALAEWNKLNPSIKQPLKKKLIKVLENPHIPKNKLSGHPNRYKIKLRSVGYRLVYEVIDDEVVVIVIAVGR
RENNAVYDEANSRHS

Download         Length: 288 bp

>T225347 NZ_CP121137:2817208-2817426 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9246.72 Da        Isoelectric Point: 5.0491

>AT225347 WP_000192612.1 NZ_CP087318:15363-15611 [Acinetobacter baumannii]
MTQLIHARMTASITELKKSPMDTVLAGKGEPVAILNRNTPAFYCVPADLYETMMEQLEDLELNKIADARANQKRIRVNID
DL

Download         Length: 249 bp

>AT225347 NZ_CP121137:2816807-2817181 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3Y3F8

Antitoxin

Source ID Structure
AlphaFold DB R9B9T8

References