Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3376337..3376990 Replicon chromosome
Accession NZ_CP087312
Organism Acinetobacter baumannii strain OC059

Toxin (Protein)


Gene name cptA Uniprot ID A0A858S2K0
Locus tag LO007_RS15925 Protein ID WP_031999513.1
Coordinates 3376337..3376726 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag LO007_RS15930 Protein ID WP_001288210.1
Coordinates 3376733..3376990 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO007_RS15910 3371455..3373650 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
LO007_RS15915 3373838..3374404 - 567 WP_000651536.1 rhombosortase -
LO007_RS15920 3374482..3375567 - 1086 WP_031999514.1 hypothetical protein -
LO007_RS15925 3376337..3376726 - 390 WP_031999513.1 membrane protein Toxin
LO007_RS15930 3376733..3376990 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
LO007_RS15935 3377178..3378350 + 1173 WP_017725189.1 acyl-CoA dehydrogenase family protein -
LO007_RS15940 3378399..3379889 - 1491 WP_000415132.1 NAD(P)/FAD-dependent oxidoreductase -
LO007_RS15945 3380071..3380448 - 378 WP_001216380.1 50S ribosomal protein L17 -
LO007_RS15950 3380467..3381474 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15598.85 Da        Isoelectric Point: 10.3889

>T225343 WP_031999513.1 NZ_CP087312:c3376726-3376337 [Acinetobacter baumannii]
MVNHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYQSQNTV
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T225343 NZ_CP121135:c4567472-4567370 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT225343 WP_001288210.1 NZ_CP087312:c3376990-3376733 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT225343 NZ_CP121135:4567363-4567508 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A858S2K0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References