Detailed information of TA system TA225340

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2165935..2166614
• Replicon: chromosome
• Accession: NZ_CP087309
• Organism: Acinetobacter baumannii strain OC068

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: LO005_RS10320
• Protein ID: WP_000838146.1
• Coordinates: 2166432..2166614 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: LO005_RS10315
• Protein ID: WP_000966688.1
• Coordinates: 2165935..2166339 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO005_RS10305	2164891..2165154	-	264	WP_001275792.1	hypothetical protein	-
LO005_RS10310	2165156..2165836	-	681	WP_000721572.1	hypothetical protein	-
LO005_RS10315	2165935..2166339	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LO005_RS10320	2166432..2166614	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
LO005_RS10325	2166940..2167455	-	516	WP_024616020.1	hypothetical protein	-
LO005_RS10330	2167526..2168443	-	918	WP_000094253.1	phage tail tube protein	-
LO005_RS10335	2168496..2169851	-	1356	WP_000002416.1	hypothetical protein	-
LO005_RS10340	2169851..2170204	-	354	WP_057078257.1	hypothetical protein	-
LO005_RS10345	2170319..2170546	-	228	WP_057078256.1	hypothetical protein	-
LO005_RS10350	2170548..2170946	-	399	WP_057078255.1	phage tail terminator-like protein	-
LO005_RS10355	2170948..2171316	-	369	WP_025468552.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2018999..2215908	196909

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T225340 WP_000838146.1 NZ_CP087309:c2166614-2166432 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T225340 NZ_CP121135:1892876-1893409 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTAGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT225340 WP_000966688.1 NZ_CP087309:c2166339-2165935 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT225340 NZ_CP121135:1892599-1892865 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6