Detailed information of TA system TA225339

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 445919..446572
• Replicon: chromosome
• Accession: NZ_CP087309
• Organism: Acinetobacter baumannii strain OC068

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A9E9PBS3
• Locus tag: LO005_RS02185
• Protein ID: WP_002096593.1
• Coordinates: 446183..446572 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A2G8V6F0
• Locus tag: LO005_RS02180
• Protein ID: WP_029424136.1
• Coordinates: 445919..446176 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO005_RS02160	441435..442442	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
LO005_RS02165	442461..442838	+	378	WP_001216380.1	50S ribosomal protein L17	-
LO005_RS02170	443020..444510	+	1491	WP_000415132.1	NAD(P)/FAD-dependent oxidoreductase	-
LO005_RS02175	444559..445731	-	1173	WP_001190550.1	acyl-CoA dehydrogenase family protein	-
LO005_RS02180	445919..446176	+	258	WP_029424136.1	succinate dehydrogenase assembly factor 2	Antitoxin
LO005_RS02185	446183..446572	+	390	WP_002096593.1	hypothetical protein	Toxin
LO005_RS02190	447342..448427	+	1086	WP_000049106.1	hypothetical protein	-
LO005_RS02195	448505..449071	+	567	WP_000651536.1	rhombosortase	-
LO005_RS02200	449259..451454	+	2196	WP_001158905.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-80)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15677.99 Da
• Isoelectric Point: 10.3890

>T225339 WP_002096593.1 NZ_CP087309:446183-446572 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLVEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T225339 NZ_CP121135:1778536-1778820 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTTAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10360.85 Da
• Isoelectric Point: 4.4909

>AT225339 WP_029424136.1 NZ_CP087309:445919-446176 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADLAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
YYVHG

Nucleotide

• Length: 258 bp

>AT225339 NZ_CP121135:1778304-1778546 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCTGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A2G8V6F0