Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3241838..3242491 Replicon chromosome
Accession NZ_CP087300
Organism Acinetobacter baumannii strain OC061

Toxin (Protein)


Gene name cptA Uniprot ID A0A2S4T466
Locus tag LO014_RS16195 Protein ID WP_000607071.1
Coordinates 3241838..3242227 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID N9LG27
Locus tag LO014_RS16200 Protein ID WP_001288212.1
Coordinates 3242234..3242491 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO014_RS16175 3237467..3238675 + 1209 WP_000343018.1 IS256-like element ISAba26 family transposase -
LO014_RS16180 3238711..3239151 - 441 Protein_3152 hypothetical protein -
LO014_RS16185 3239339..3239905 - 567 WP_000651536.1 rhombosortase -
LO014_RS16190 3239983..3241068 - 1086 WP_000049106.1 hypothetical protein -
LO014_RS16195 3241838..3242227 - 390 WP_000607071.1 membrane protein Toxin
LO014_RS16200 3242234..3242491 - 258 WP_001288212.1 succinate dehydrogenase assembly factor 2 Antitoxin
LO014_RS16205 3242679..3243851 + 1173 WP_001190557.1 acyl-CoA dehydrogenase family protein -
LO014_RS16210 3243898..3245388 - 1491 WP_000415120.1 NAD(P)/FAD-dependent oxidoreductase -
LO014_RS16215 3245570..3245947 - 378 WP_001216380.1 50S ribosomal protein L17 -
LO014_RS16220 3245966..3246973 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3237467..3238675 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T225337 WP_000607071.1 NZ_CP087300:c3242227-3241838 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T225337 NZ_CP121135:1296570-1296953 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCATCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10332.79 Da        Isoelectric Point: 4.6247

>AT225337 WP_001288212.1 NZ_CP087300:c3242491-3242234 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKAEPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT225337 NZ_CP121135:1296328-1296570 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4T466

Antitoxin

Source ID Structure
AlphaFold DB N9LG27

References