Detailed information of TA system TA225336

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1268927..1269606
• Replicon: chromosome
• Accession: NZ_CP087300
• Organism: Acinetobacter baumannii strain OC061

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: LO014_RS06370
• Protein ID: WP_000838146.1
• Coordinates: 1268927..1269109 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: LO014_RS06375
• Protein ID: WP_000966688.1
• Coordinates: 1269202..1269606 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO014_RS06335	1264116..1264523	+	408	WP_057690438.1	hypothetical protein	-
LO014_RS06340	1264495..1264863	+	369	WP_258584246.1	HK97 gp10 family phage protein	-
LO014_RS06345	1264865..1265263	+	399	WP_101433611.1	phage tail terminator-like protein	-
LO014_RS06350	1265332..1265685	+	354	WP_000064602.1	hypothetical protein	-
LO014_RS06355	1265685..1267046	+	1362	WP_258584172.1	phage tail protein	-
LO014_RS06360	1267099..1268016	+	918	WP_258584173.1	phage tail tube protein	-
LO014_RS06365	1268086..1268601	+	516	WP_032063623.1	hypothetical protein	-
LO014_RS06370	1268927..1269109	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
LO014_RS06375	1269202..1269606	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LO014_RS06380	1269688..1270065	+	378	WP_000720074.1	hypothetical protein	-
LO014_RS06385	1270167..1271603	+	1437	Protein_1234	tape measure protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1229145..1297861	68716

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T225336 WP_000838146.1 NZ_CP087300:1268927-1269109 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T225336 NZ_CP121135:c1018924-1018439 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATGCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT225336 WP_000966688.1 NZ_CP087300:1269202-1269606 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT225336 NZ_CP121135:c1019178-1018912 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6