Detailed information of TA system TA225333

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3487441..3488094
• Replicon: chromosome
• Accession: NZ_CP087298
• Organism: Acinetobacter baumannii strain OC070

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A9E9PBS3
• Locus tag: LO009_RS16635
• Protein ID: WP_002096593.1
• Coordinates: 3487441..3487830 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: LO009_RS16640
• Protein ID: WP_001288210.1
• Coordinates: 3487837..3488094 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO009_RS16620	3482558..3484753	-	2196	WP_001158905.1	TRAP transporter large permease subunit	-
LO009_RS16625	3484941..3485507	-	567	WP_000651536.1	rhombosortase	-
LO009_RS16630	3485585..3486670	-	1086	WP_000049106.1	hypothetical protein	-
LO009_RS16635	3487441..3487830	-	390	WP_002096593.1	hypothetical protein	Toxin
LO009_RS16640	3487837..3488094	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
LO009_RS16645	3488282..3489454	+	1173	WP_004839681.1	acyl-CoA dehydrogenase family protein	-
LO009_RS16650	3489503..3490993	-	1491	WP_045900148.1	NAD(P)/FAD-dependent oxidoreductase	-
LO009_RS16655	3491175..3491552	-	378	WP_001216380.1	50S ribosomal protein L17	-
LO009_RS16660	3491571..3492578	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15677.99 Da
• Isoelectric Point: 10.3890

>T225333 WP_002096593.1 NZ_CP087298:c3487830-3487441 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLVEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T225333 NZ_CP121135:c421933-421523 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGATGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT225333 WP_001288210.1 NZ_CP087298:c3488094-3487837 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT225333 NZ_CP121135:c422180-421914 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7