Detailed information of TA system TA225331

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1282527..1283206
• Replicon: chromosome
• Accession: NZ_CP087298
• Organism: Acinetobacter baumannii strain OC070

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: LO009_RS06245
• Protein ID: WP_000838146.1
• Coordinates: 1282527..1282709 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: LO009_RS06250
• Protein ID: WP_000966688.1
• Coordinates: 1282802..1283206 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO009_RS06205	1277596..1277964	+	369	WP_047481099.1	hypothetical protein	-
LO009_RS06210	1277966..1278364	+	399	WP_138150228.1	phage tail terminator-like protein	-
LO009_RS06215	1278366..1278584	+	219	WP_138150226.1	hypothetical protein	-
LO009_RS06220	1278693..1279214	+	522	WP_138150224.1	SH3 domain-containing protein	-
LO009_RS06225	1279311..1279661	+	351	WP_138150222.1	hypothetical protein	-
LO009_RS06230	1279661..1280644	+	984	WP_138150219.1	pyocin knob domain-containing protein	-
LO009_RS06235	1280697..1281614	+	918	WP_138150216.1	phage tail tube protein	-
LO009_RS06240	1281686..1282201	+	516	WP_138150193.1	hypothetical protein	-
LO009_RS06245	1282527..1282709	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
LO009_RS06250	1282802..1283206	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LO009_RS06255	1283288..1283665	+	378	WP_000720074.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1251659..1302498	50839

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T225331 WP_000838146.1 NZ_CP087298:1282527-1282709 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T225331 NZ_CP121133:c5069560-5069075 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATGCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT225331 WP_000966688.1 NZ_CP087298:1282802-1283206 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT225331 NZ_CP121133:c5069814-5069548 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6