Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1060509..1062192 Replicon chromosome
Accession NC_010002
Organism Delftia acidovorans SPH-1

Toxin (Protein)


Gene name doc Uniprot ID A9BQI6
Locus tag DACI_RS04830 Protein ID WP_012202882.1
Coordinates 1060509..1061363 (+) Length 285 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID F6ALN8
Locus tag DACI_RS04835 Protein ID WP_012202883.1
Coordinates 1061386..1062192 (+) Length 269 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DACI_RS04810 1056520..1057341 + 822 WP_012202877.1 2,5-didehydrogluconate reductase DkgB -
DACI_RS04815 1057498..1059177 + 1680 WP_012202878.1 long-chain-fatty-acid--CoA ligase -
DACI_RS31830 1059246..1059443 - 198 WP_192812337.1 hypothetical protein -
DACI_RS04820 1059371..1059778 + 408 WP_080518167.1 Lrp/AsnC family transcriptional regulator -
DACI_RS04825 1059964..1060494 + 531 WP_012202881.1 cupin domain-containing protein -
DACI_RS04830 1060509..1061363 + 855 WP_012202882.1 alpha/beta fold hydrolase Toxin
DACI_RS04835 1061386..1062192 + 807 WP_012202883.1 IclR family transcriptional regulator Antitoxin
DACI_RS04840 1062247..1063044 + 798 WP_043780656.1 aspartate dehydrogenase -
DACI_RS04845 1063156..1063911 + 756 WP_012202885.1 5'-methylthioadenosine/adenosylhomocysteine nucleosidase -
DACI_RS04850 1064136..1065323 + 1188 WP_012202886.1 IS481 family transposase -
DACI_RS30955 1065602..1065877 - 276 WP_012202887.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(43-270)

Antitoxin

Transcription regulator IclR, C-terminal

(137-255)


Sequences

Toxin        


Download         Length: 285 a.a.        Molecular weight: 29659.91 Da        Isoelectric Point: 6.7493

>T22531 WP_012202882.1 NC_010002:1060509-1061363 [Delftia acidovorans SPH-1]
MTAQTLQRMEQRLQTQFPEHLIALPGGAQAAWREAGDTASDFAVVMLHGISSGAASWLDVALELAPRARVLAWDAPGYGR
STPLAPDAPTGADYARVLEQSLQALGVRRCLLVGHSLGALMGTPWAVQAGAGRVQQLVLISPAGGYGAPGMGEQQAKVRQ
GRLAALQEKGIEGLAAAIDQRLVSPAAPEPVRQWVRWNTARLHAAGYAQAVELLCGSDLGQAAGQLAMPVEVWVGEHDVV
TPPAACAAWAARLGARYVTLAAAGHASVVEQPADVAQRLATLLT

Download         Length: 855 bp

>T22531 NC_010002:1060509-1061363 [Delftia acidovorans SPH-1]
ATGACCGCGCAGACGCTGCAGCGCATGGAACAGCGCCTTCAGACGCAGTTCCCCGAACACCTCATCGCCCTGCCCGGTGG
CGCTCAGGCCGCCTGGCGCGAGGCCGGCGACACGGCCTCGGACTTTGCCGTGGTGATGCTGCACGGCATCAGCTCGGGCG
CCGCCTCCTGGCTGGACGTGGCCCTGGAGCTGGCGCCGCGCGCGCGTGTGCTGGCCTGGGACGCGCCCGGCTATGGCCGC
TCCACGCCGCTGGCACCCGACGCGCCCACGGGCGCCGACTACGCCCGCGTGCTGGAGCAGTCGCTGCAGGCGCTGGGCGT
GCGCCGCTGCCTGCTGGTGGGCCACTCGCTGGGTGCGCTCATGGGCACGCCCTGGGCGGTGCAGGCCGGTGCCGGGCGCG
TGCAGCAACTGGTGCTGATCAGCCCCGCTGGCGGCTATGGCGCACCCGGCATGGGCGAGCAGCAGGCCAAGGTACGCCAG
GGCCGTCTTGCGGCCCTTCAGGAAAAAGGCATCGAAGGCCTGGCCGCCGCCATCGACCAGCGCCTGGTCTCGCCCGCCGC
GCCCGAGCCCGTGCGCCAATGGGTGCGCTGGAACACGGCGCGCCTGCATGCTGCCGGCTACGCCCAGGCCGTGGAGCTGC
TGTGCGGCAGCGACCTGGGGCAGGCGGCGGGGCAACTGGCCATGCCGGTCGAGGTCTGGGTGGGAGAGCACGACGTGGTC
ACGCCGCCCGCCGCCTGTGCGGCCTGGGCCGCAAGGCTGGGCGCCCGGTACGTTACGCTTGCGGCAGCCGGCCATGCCTC
TGTCGTCGAACAACCTGCGGATGTCGCACAGAGGCTGGCCACCCTGCTGACCTGA

Antitoxin


Download         Length: 269 a.a.        Molecular weight: 29330.45 Da        Isoelectric Point: 5.7085

>AT22531 WP_012202883.1 NC_010002:1061386-1062192 [Delftia acidovorans SPH-1]
MSDTSETLSNDNDRYTVPALERGLRLLACFTPSQPVWSAPDLARTLALPRSTVFRMLTTLENMGYLQRSGTEYRLGLSVL
RLGYDYLSTQPLAQLAEPVLQALCERLGFTTNLALLDGTSVVYVARIAPAGAFQGAVRVGSRLPAHATVLGRALLQDMDA
DQLRELFGGSELPQFSESTPRDVQQLQQLLLQDRERGYAMGEGFYEPGVSSIAAPVRDAQGRIIAGLGMAVAFTEIAPGR
MAHWVEQVREAAVELTGHLRTQHPGFLR

Download         Length: 807 bp

>AT22531 NC_010002:1061386-1062192 [Delftia acidovorans SPH-1]
ATGAGCGACACCTCCGAAACCCTCTCGAACGACAACGACCGCTACACCGTCCCCGCGCTGGAGCGCGGCCTGCGCCTGCT
GGCCTGCTTCACGCCTTCGCAGCCCGTGTGGAGCGCGCCCGACCTGGCGCGCACCCTGGCGCTGCCGCGTTCCACGGTGT
TCCGGATGCTGACGACGCTGGAGAACATGGGGTATCTGCAACGCTCGGGCACCGAGTACCGGCTGGGCCTGTCCGTGCTG
CGCCTGGGCTACGACTACCTGTCCACCCAGCCGCTGGCCCAGCTGGCCGAGCCCGTGCTGCAGGCGCTGTGCGAGCGCCT
GGGCTTCACCACCAACCTGGCGCTGCTGGACGGCACCTCCGTAGTCTACGTGGCGCGCATCGCGCCGGCCGGCGCCTTCC
AGGGCGCCGTGCGCGTGGGCTCGCGCCTGCCGGCCCATGCCACCGTGCTGGGCCGCGCCCTGCTGCAGGACATGGACGCA
GACCAGCTGCGCGAACTCTTCGGCGGCAGCGAGCTGCCGCAATTCTCGGAAAGCACCCCGCGCGACGTGCAGCAACTGCA
GCAGTTGCTGCTGCAGGACCGCGAGCGCGGCTACGCCATGGGCGAGGGCTTCTACGAGCCCGGCGTCTCCAGCATTGCCG
CACCCGTGCGCGATGCGCAGGGCCGCATCATCGCGGGCCTGGGCATGGCCGTGGCCTTTACCGAAATCGCACCCGGGCGC
ATGGCGCACTGGGTGGAACAGGTGCGCGAGGCCGCCGTCGAACTGACGGGCCACCTGCGCACCCAGCATCCTGGTTTTCT
GCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A9BQI6

Antitoxin

Source ID Structure
AlphaFold DB A0A031HDN8

References