Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1113310..1113928 Replicon chromosome
Accession NZ_CP087294
Organism Escherichia coli strain APEC E956

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LO740_RS05255 Protein ID WP_001291435.1
Coordinates 1113310..1113528 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LO740_RS05260 Protein ID WP_000344800.1
Coordinates 1113554..1113928 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO740_RS05220 (1108599) 1108599..1109171 + 573 WP_000779821.1 YbaY family lipoprotein -
LO740_RS05225 (1109202) 1109202..1109513 - 312 WP_000409911.1 MGMT family protein -
LO740_RS05235 (1109892) 1109892..1110245 + 354 WP_000878140.1 DUF1428 domain-containing protein -
LO740_RS05240 (1110287) 1110287..1111837 - 1551 WP_001317659.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LO740_RS05245 (1112001) 1112001..1112471 - 471 WP_000136192.1 YlaC family protein -
LO740_RS05250 (1112587) 1112587..1113138 - 552 WP_000102564.1 maltose O-acetyltransferase -
LO740_RS05255 (1113310) 1113310..1113528 - 219 WP_001291435.1 HHA domain-containing protein Toxin
LO740_RS05260 (1113554) 1113554..1113928 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LO740_RS05265 (1114474) 1114474..1117623 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
LO740_RS05270 (1117646) 1117646..1118839 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T225302 WP_001291435.1 NZ_CP087294:c1113528-1113310 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T225302 NZ_CP121129:c3193797-3193695 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT225302 WP_000344800.1 NZ_CP087294:c1113928-1113554 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT225302 NZ_CP121129:3193688-3193833 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References