Detailed information of TA system TA022529

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 3574..4145
• Replicon: plasmid pS19503
• Accession: NC_010000
• Organism: Shewanella baltica OS195

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A9L6P3
• Locus tag: SBAL195_RS24040
• Protein ID: WP_012197990.1
• Coordinates: 3834..4145 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A9L6P2
• Locus tag: SBAL195_RS24035
• Protein ID: WP_012197989.1
• Coordinates: 3574..3834 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBAL195_RS24025	58..237	+	180	WP_012197987.1	hypothetical protein	-
SBAL195_RS24030	230..3463	+	3234	WP_012197988.1	DUF1738 domain-containing protein	-
SBAL195_RS24035	3574..3834	+	261	WP_012197989.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SBAL195_RS24040	3834..4145	+	312	WP_012197990.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SBAL195_RS24045	4189..6330	-	2142	WP_012197991.1	relaxase/mobilization nuclease domain-containing protein	-
SBAL195_RS24050	6327..6701	-	375	WP_012197992.1	conjugal transfer transcriptional regulator TraJ	-
SBAL195_RS24055	7117..7470	+	354	WP_012197993.1	hypothetical protein	-
SBAL195_RS24060	7512..8234	+	723	WP_012197994.1	conjugal transfer protein TraL	-
SBAL195_RS24065	8231..8689	+	459	WP_012197995.1	conjugal transfer protein TraM	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..49148	49148

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-59)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11963.78 Da
• Isoelectric Point: 7.4646

>T22529 WP_012197990.1 NC_010000:3834-4145 [Shewanella baltica OS195]
MPLYHLTQEAQSDLIEIRRYTVQQWGDVQSKKYLSELEQTIQLLATNPRLGRLKPDVGSNVMSFPHASHVIYYVTNEPQL
IVFGVLHKRMVPFNHLGERDMIS

Nucleotide

• Length: 312 bp

>T22529 NC_010000:3834-4145 [Shewanella baltica OS195]
ATGCCGCTCTATCACTTAACCCAAGAGGCTCAATCAGATCTCATTGAAATCCGTCGTTACACCGTCCAGCAATGGGGGGA
CGTTCAATCAAAAAAATACCTGTCTGAACTCGAACAAACCATTCAATTACTTGCCACTAACCCTCGGCTGGGCAGACTAA
AACCGGATGTAGGGTCTAATGTAATGAGTTTCCCCCACGCCAGCCATGTGATCTATTATGTTACGAATGAGCCCCAATTA
ATTGTATTTGGTGTGCTTCACAAGCGCATGGTTCCCTTTAATCACTTAGGTGAACGAGATATGATTTCATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9516.96 Da
• Isoelectric Point: 6.4631

>AT22529 WP_012197989.1 NC_010000:3574-3834 [Shewanella baltica OS195]
MDMLTANEAKTHFGEVLLKAQQAPIQINKNGKPVAVVISVDEYNSIEVLKLRLLQSRAAHIKTDMATGKLVEGESFFNAL
KEGQYD

Nucleotide

• Length: 261 bp

>AT22529 NC_010000:3574-3834 [Shewanella baltica OS195]
ATGGATATGCTTACAGCAAACGAAGCTAAAACACATTTCGGAGAGGTGTTGTTAAAAGCTCAGCAAGCACCAATTCAAAT
CAATAAGAACGGCAAACCTGTTGCTGTAGTAATCTCAGTTGATGAATATAACTCTATAGAAGTGCTCAAATTGCGATTAT
TGCAATCAAGAGCAGCTCACATTAAAACAGATATGGCCACGGGCAAGTTGGTTGAGGGTGAATCATTTTTTAATGCCCTA
AAAGAAGGCCAATACGACTAA

Structures

Toxin

• AlphaFold DB: A9L6P3

Antitoxin

• AlphaFold DB: A9L6P2