Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 56003..56562 | Replicon | plasmid p102026_1 |
| Accession | NZ_CP087291 | ||
| Organism | Escherichia coli strain APEC 102026 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A0H2XJR9 |
| Locus tag | LO741_RS25925 | Protein ID | WP_000421266.1 |
| Coordinates | 56003..56278 (-) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A0H2XL20 |
| Locus tag | LO741_RS25930 | Protein ID | WP_012006537.1 |
| Coordinates | 56278..56562 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LO741_RS25900 (51023) | 51023..51253 | + | 231 | WP_001261287.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| LO741_RS25905 (51250) | 51250..51666 | + | 417 | WP_001044768.1 | type II toxin-antitoxin system VapC family toxin | - |
| LO741_RS25910 (51828) | 51828..53966 | - | 2139 | WP_000350635.1 | AAA family ATPase | - |
| LO741_RS25915 (54324) | 54324..55495 | + | 1172 | WP_094284492.1 | IS91 family transposase | - |
| LO741_RS25920 (55658) | 55658..55897 | - | 240 | WP_001105068.1 | hypothetical protein | - |
| LO741_RS25925 (56003) | 56003..56278 | - | 276 | WP_000421266.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LO741_RS25930 (56278) | 56278..56562 | - | 285 | WP_012006537.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| LO741_RS25935 (57063) | 57063..57653 | + | 591 | WP_000086535.1 | recombinase family protein | - |
| LO741_RS25940 (57700) | 57700..57858 | + | 159 | Protein_55 | integrase core domain-containing protein | - |
| LO741_RS25945 (58008) | 58008..59006 | + | 999 | WP_000756335.1 | ABC transporter substrate-binding protein | - |
| LO741_RS25950 (59006) | 59006..60043 | + | 1038 | WP_000110580.1 | iron ABC transporter permease | - |
| LO741_RS25955 (60043) | 60043..60804 | + | 762 | WP_000020503.1 | ABC transporter ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sitABCD | iroB / iroC / iroD / iroE / iroN / vat / iutA / iucD / iucC / iucB / iucA | 1..174489 | 174489 | |
| - | inside | IScluster/Tn | - | - | 54668..73764 | 19096 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10779.47 Da Isoelectric Point: 9.9324
>T225289 WP_000421266.1 NZ_CP087291:c56278-56003 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAATRTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR
MELKWTSKALSDLARLYDFLVLASKPAATRTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR
Download Length: 276 bp
>T225289 NZ_CP121127:c4271383-4270850 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTAGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTAGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10501.96 Da Isoelectric Point: 6.4632
>AT225289 WP_012006537.1 NZ_CP087291:c56562-56278 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVKSGQVIDHQAVQAW
ADSLSTDNPLPVPR
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVKSGQVIDHQAVQAW
ADSLSTDNPLPVPR
Download Length: 285 bp
>AT225289 NZ_CP121127:c4271660-4271394 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H2XJR9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H2XL20 |