Detailed information of TA system TA022528

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 57378..57894
• Replicon: plasmid pS19502
• Accession: NC_009999
• Organism: Shewanella baltica OS195

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B8EFR1
• Locus tag: SBAL195_RS23930
• Protein ID: WP_011979492.1
• Coordinates: 57610..57894 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B8EFR0
• Locus tag: SBAL195_RS23925
• Protein ID: WP_011979491.1
• Coordinates: 57378..57620 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBAL195_RS23900	52845..54035	-	1191	WP_012197979.1	DUF262 domain-containing protein	-
SBAL195_RS23905	54526..55485	+	960	WP_012197980.1	integron integrase	-
SBAL195_RS23910	55641..55919	+	279	WP_150102380.1	hypothetical protein	-
SBAL195_RS23915	56066..56686	+	621	WP_011979489.1	DUF2913 family protein	-
SBAL195_RS23920	56779..57051	+	273	WP_011979490.1	hypothetical protein	-
SBAL195_RS23925	57378..57620	+	243	WP_011979491.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
SBAL195_RS23930	57610..57894	+	285	WP_011979492.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SBAL195_RS23935	58093..59016	+	924	WP_011979493.1	IS5 family transposase	-
SBAL195_RS23940	59220..60248	+	1029	WP_011979494.1	IS110 family transposase	-
SBAL195_RS23955	61708..62747	-	1040	Protein_59	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..75508	75508

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11079.11 Da
• Isoelectric Point: 10.5812

>T22528 WP_011979492.1 NC_009999:57610-57894 [Shewanella baltica OS195]
MIYKLVFDPRALKEWNKLGDPIRQQLKKKLAEILQHPHIGANKLRDLPDCYKIKLRTSGYRLVYQVQDERITVFVVAVGK
RERLAVYSTAEKRL

Nucleotide

• Length: 285 bp

>T22528 NC_009999:57610-57894 [Shewanella baltica OS195]
ATGATCTATAAGTTAGTATTTGATCCCCGCGCATTAAAGGAATGGAACAAGCTTGGAGATCCCATCAGGCAGCAGTTAAA
AAAGAAACTGGCCGAGATACTGCAACATCCTCATATCGGGGCTAACAAACTTAGAGATCTCCCTGACTGTTACAAAATCA
AGTTGCGTACATCAGGTTATCGCTTGGTATATCAAGTACAAGATGAACGCATTACCGTGTTTGTCGTGGCCGTAGGCAAG
CGTGAACGATTAGCGGTGTATTCAACAGCAGAAAAGCGCCTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8816.24 Da
• Isoelectric Point: 4.4501

>AT22528 WP_011979491.1 NC_009999:57378-57620 [Shewanella baltica OS195]
MGTINIRIDDELKERSFAVLEKLGVSPSEALRQMLEYVATSGAMPFKPVLLTAEDEALISLVKERLASPRKGIEVSLDDL

Nucleotide

• Length: 243 bp

>AT22528 NC_009999:57378-57620 [Shewanella baltica OS195]
ATGGGCACTATTAATATTCGCATCGATGACGAGCTTAAGGAGCGTTCTTTTGCTGTGTTGGAAAAATTAGGCGTTAGTCC
CTCTGAGGCATTGCGGCAAATGCTTGAGTATGTCGCCACAAGCGGCGCTATGCCATTTAAACCCGTACTGCTAACAGCAG
AGGATGAAGCCTTGATCTCCTTGGTTAAAGAGCGTTTAGCGAGCCCTCGAAAGGGGATCGAGGTTTCGCTCGATGATCTA
TAA

Structures

Toxin

• AlphaFold DB: A9L6M1

Antitoxin

• AlphaFold DB: A9L6M0