Detailed information of TA system TA022527

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /ElaA(toxin)
• Location: 15131..15980
• Replicon: plasmid pS19502
• Accession: NC_009999
• Organism: Shewanella baltica OS195

Toxin (Protein)

• Gene name: -
• Uniprot ID: B8EFS1
• Locus tag: SBAL195_RS23725
• Protein ID: WP_011979514.1
• Coordinates: 15131..15640 (+)
• Length: 170 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: SBAL195_RS23730
• Protein ID: WP_011979515.1
• Coordinates: 15753..15980 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBAL195_RS23695	11588..12043	+	456	WP_011979508.1	type II toxin-antitoxin system HicB family antitoxin	-
SBAL195_RS23700	12045..12533	+	489	WP_011979509.1	hypothetical protein	-
SBAL195_RS23705	12564..12785	+	222	WP_011979510.1	hypothetical protein	-
SBAL195_RS23710	13461..14084	+	624	WP_012589009.1	hypothetical protein	-
SBAL195_RS23715	14086..14487	+	402	WP_011979512.1	hypothetical protein	-
SBAL195_RS23720	14857..15150	+	294	WP_011979513.1	DUF1778 domain-containing protein	-
SBAL195_RS23725	15131..15640	+	510	WP_011979514.1	GNAT family N-acetyltransferase	Toxin
SBAL195_RS23730	15753..15980	+	228	WP_011979515.1	hypothetical protein	Antitoxin
SBAL195_RS23735	16555..17553	+	999	WP_011979516.1	DUF1738 domain-containing protein	-
SBAL195_RS23740	17602..17901	+	300	WP_011979517.1	hypothetical protein	-
SBAL195_RS23745	18459..18818	+	360	WP_006087379.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..75508	75508

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (80-143)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 170 a.a.
• Molecular weight: 19129.15 Da
• Isoelectric Point: 8.3399

>T22527 WP_011979514.1 NC_009999:15131-15640 [Shewanella baltica OS195]
MKITQFDKNEHDRKSFDCGNTELNNYLKCISGQHEKKDISRTYVLTSELNPSHIKGYYSIAVAQVSLCELPTEIAKKYPS
EITCSLIGRMAVNHTCQRQGLGSILLIDAIKRIIQASSAIPIPMIIVQAKNEDARRFYSEFGFVSFPDNYLKLMMTLAHA
KAMLKEAEH

Nucleotide

• Length: 510 bp

>T22527 NC_009999:15131-15640 [Shewanella baltica OS195]
ATGAAAATTACCCAATTTGATAAAAATGAGCATGACCGTAAGAGTTTTGATTGTGGGAATACAGAGCTAAACAATTACCT
GAAATGCATTTCAGGTCAGCATGAAAAGAAAGATATTTCAAGAACATATGTTCTTACTTCAGAGTTAAATCCTTCACACA
TAAAAGGTTATTACTCTATTGCGGTAGCTCAGGTATCACTTTGTGAGTTACCAACCGAAATAGCTAAAAAATATCCATCT
GAAATAACGTGTAGCTTGATAGGTCGAATGGCTGTTAACCATACCTGTCAAAGACAAGGGCTTGGCTCAATATTGCTTAT
AGACGCAATCAAACGAATTATCCAAGCTTCCAGTGCTATCCCCATCCCTATGATTATTGTTCAAGCAAAGAACGAAGATG
CTAGACGTTTTTATAGTGAGTTTGGTTTTGTATCCTTTCCTGATAATTATTTGAAACTCATGATGACACTGGCCCATGCT
AAAGCGATGTTGAAAGAAGCCGAACATTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8335.43 Da
• Isoelectric Point: 3.8074

>AT22527 WP_011979515.1 NC_009999:15753-15980 [Shewanella baltica OS195]
MMQNAMTFKGYHGSVEISPEDNILFGQVLFISPLINYEAETAKELEQAFQEAINAYLADCVQQDIPPEKALEGIA

Nucleotide

• Length: 228 bp

>AT22527 NC_009999:15753-15980 [Shewanella baltica OS195]
ATGATGCAAAATGCAATGACATTTAAGGGTTATCACGGCTCTGTAGAAATCAGCCCAGAGGATAATATTCTGTTTGGGCA
GGTGTTATTCATTTCACCGTTGATCAACTATGAGGCCGAAACCGCCAAAGAGTTAGAGCAAGCATTTCAAGAGGCGATTA
ACGCTTATCTTGCTGATTGTGTTCAACAGGACATTCCGCCAGAGAAAGCCTTGGAAGGGATAGCTTAA

Structures

Toxin

• AlphaFold DB: A9L6I1