Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/DUF4065(antitoxin) |
| Location | 2695702..2696627 | Replicon | chromosome |
| Accession | NZ_CP087290 | ||
| Organism | Escherichia coli strain APEC 102026 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | LO741_RS13000 | Protein ID | WP_014640052.1 |
| Coordinates | 2696241..2696627 (+) | Length | 129 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | - |
| Locus tag | LO741_RS12995 | Protein ID | WP_024174200.1 |
| Coordinates | 2695702..2696211 (+) | Length | 170 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LO741_RS12970 (2691801) | 2691801..2692169 | + | 369 | WP_000002907.1 | diacylglycerol kinase | - |
| LO741_RS12975 (2692279) | 2692279..2692887 | + | 609 | WP_000646078.1 | transcriptional repressor LexA | - |
| LO741_RS12980 (2692960) | 2692960..2694285 | + | 1326 | WP_001318177.1 | MATE family efflux transporter DinF | - |
| LO741_RS12985 (2694401) | 2694401..2694610 | + | 210 | WP_001296638.1 | CsbD family protein | - |
| LO741_RS12990 (2694652) | 2694652..2695167 | - | 516 | WP_000416264.1 | zinc uptake transcriptional repressor Zur | - |
| LO741_RS12995 (2695702) | 2695702..2696211 | + | 510 | WP_024174200.1 | Panacea domain-containing protein | Antitoxin |
| LO741_RS13000 (2696241) | 2696241..2696627 | + | 387 | WP_014640052.1 | hypothetical protein | Toxin |
| LO741_RS13005 (2696667) | 2696667..2696840 | + | 174 | WP_165386319.1 | hypothetical protein | - |
| LO741_RS13010 (2696888) | 2696888..2697169 | - | 282 | WP_039023331.1 | pyocin activator PrtN family protein | - |
| LO741_RS13015 (2697206) | 2697206..2697778 | - | 573 | WP_052970437.1 | 3'-5' exonuclease | - |
| LO741_RS13020 (2697778) | 2697778..2697939 | - | 162 | WP_230989213.1 | DUF551 domain-containing protein | - |
| LO741_RS13025 (2698171) | 2698171..2698296 | - | 126 | Protein_2532 | hypothetical protein | - |
| LO741_RS13030 (2698299) | 2698299..2698490 | - | 192 | WP_052970435.1 | hypothetical protein | - |
| LO741_RS13035 (2698492) | 2698492..2699214 | - | 723 | WP_052970434.1 | ead/Ea22-like family protein | - |
| LO741_RS13040 (2699211) | 2699211..2699450 | - | 240 | WP_000476211.1 | hypothetical protein | - |
| LO741_RS13045 (2699443) | 2699443..2699646 | - | 204 | WP_000111289.1 | hypothetical protein | - |
| LO741_RS13050 (2699643) | 2699643..2700005 | - | 363 | WP_001242718.1 | phage protein | - |
| LO741_RS13055 (2699996) | 2699996..2700532 | - | 537 | WP_001401560.1 | 5'-deoxynucleotidase | - |
| LO741_RS13060 (2700660) | 2700660..2701484 | - | 825 | WP_052970433.1 | DUF2303 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2692279..2752517 | 60238 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 129 a.a. Molecular weight: 14465.40 Da Isoelectric Point: 5.4833
>T225266 WP_014640052.1 NZ_CP087290:2696241-2696627 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE
Download Length: 387 bp
>T225266 NZ_CP121088:88375-88773 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA
Antitoxin
Download Length: 170 a.a. Molecular weight: 19559.39 Da Isoelectric Point: 5.3338
>AT225266 WP_024174200.1 NZ_CP087290:2695702-2696211 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS
Download Length: 510 bp
>AT225266 NZ_CP121088:88148-88375 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|