Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 735204..735829 Replicon chromosome
Accession NZ_CP087290
Organism Escherichia coli strain APEC 102026

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag LO741_RS03475 Protein ID WP_000911329.1
Coordinates 735204..735602 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag LO741_RS03480 Protein ID WP_000450524.1
Coordinates 735602..735829 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO741_RS03455 (731111) 731111..731311 + 201 WP_000383836.1 YpfN family protein -
LO741_RS03460 (731392) 731392..732090 - 699 WP_000679819.1 esterase -
LO741_RS03465 (732164) 732164..734179 - 2016 WP_000829310.1 tRNA cytosine(34) acetyltransferase TmcA -
LO741_RS03470 (734194) 734194..735057 - 864 WP_001267498.1 neutral zinc metallopeptidase -
LO741_RS03475 (735204) 735204..735602 - 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
LO741_RS03480 (735602) 735602..735829 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
LO741_RS03485 (735986) 735986..736699 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
LO741_RS03490 (736912) 736912..737946 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
LO741_RS03495 (737963) 737963..738841 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
LO741_RS03500 (738987) 738987..739559 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
LO741_RS03505 (739559) 739559..740029 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T225252 WP_000911329.1 NZ_CP087290:c735602-735204 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T225252 NZ_CP121087:c2034956-2034615 [Escherichia coli]
ATGTGGGACGTCGAGACAACGGAGACTTTCGACAACTGGTTTGATGCCCAGACTGTTGCGCTGAAAGAAGATTTACTTGC
TGCAATGCTGATTCTTGCTGAGTATGGCCCACAGTTGGGCAGACCCTTTGCGGATACGGTTAATGATTCACAGTTTTCAA
ATATGAAAGAATTACGCGTCCAACATCAGGGAAACCCGGTACGTGCTTTTTTTGCTTTCGATCCTGCGCGCCGTGGCATT
GTATTATGTGCGGGTGATAAAACGGGGTTAAATGAGAAAAAGTTTTATCGCGATATGATCAAGCTCGCTGATTCTGAATA
CCGTAAGCATCTGAAAAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT225252 WP_000450524.1 NZ_CP087290:c735829-735602 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT225252 NZ_CP121087:c2034605-2034306 [Escherichia coli]
ATGGCTACTCTAAAAGAACTGATGGCAAAGCAAAGCCCTGAAAGCCAGGTGCGTATTGCGGCAAAAGTTGAGGAAATGCG
CCAGACCATCGCCTTGCATCAGCTGAGAGAAGAACTCAATATTTCGCAAACGGAAATGGCGGCAGCGATGGGCATTAAGC
AACCGACTCTTGCAAAAATGGAGCAGGCAGATAACGATCCTCGGTTGTCTACGCTAAAACGCTATGTTGCGGCTTTAGGT
GGGGAATTGAGTATCGACGTTAAACTGCCGAATGGTAAGAGAATTGCATTTCAGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References