Detailed information of TA system TA022525

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 63806..64386
• Replicon: plasmid pS19501
• Accession: NC_009998
• Organism: Shewanella baltica OS195

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A9L6F9
• Locus tag: SBAL195_RS23610
• Protein ID: WP_006087375.1
• Coordinates: 63806..64051 (+)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: SBAL195_RS23615
• Protein ID: WP_006087376.1
• Coordinates: 64051..64386 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBAL195_RS23585	60719..61174	+	456	WP_012197938.1	type II toxin-antitoxin system HicB family antitoxin	-
SBAL195_RS23590	61320..61664	+	345	WP_048908710.1	hypothetical protein	-
SBAL195_RS23595	61695..61916	+	222	WP_048908708.1	hypothetical protein	-
SBAL195_RS23600	62587..63210	+	624	WP_080514263.1	hypothetical protein	-
SBAL195_RS23605	63212..63613	+	402	WP_011979512.1	hypothetical protein	-
SBAL195_RS23610	63806..64051	+	246	WP_006087375.1	type II toxin-antitoxin system HicA family toxin	Toxin
SBAL195_RS23615	64051..64386	+	336	WP_006087376.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
SBAL195_RS23620	64981..65979	+	999	WP_048908709.1	DUF1738 domain-containing protein	-
SBAL195_RS23625	66028..66327	+	300	WP_012197944.1	hypothetical protein	-
SBAL195_RS23630	66886..67245	+	360	WP_006087379.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..75605	75605

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (19-71)

Antitoxin

• Uncharacterised protein family HicB (55-104)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9200.75 Da
• Isoelectric Point: 10.5259

>T22525 WP_006087375.1 NC_009998:63806-64051 [Shewanella baltica OS195]
MTKTDKLLAKLKSSKTLTWNELAGALKVLGYQQVEGDGSRVKFDNGIPKELINLHKPHPKNELKAYALRQVRDKLTEWGK
L

Nucleotide

• Length: 246 bp

>T22525 NC_009998:63806-64051 [Shewanella baltica OS195]
ATGACGAAAACGGATAAATTATTAGCAAAGCTCAAATCGTCCAAAACACTGACTTGGAATGAATTAGCGGGGGCGTTAAA
AGTGCTCGGCTATCAACAAGTCGAGGGTGATGGTTCGAGGGTTAAGTTTGATAATGGCATTCCGAAGGAGTTAATCAACC
TGCATAAACCGCATCCTAAAAATGAATTAAAGGCTTACGCATTGCGCCAAGTGAGAGACAAATTAACCGAATGGGGGAAA
CTATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12145.72 Da
• Isoelectric Point: 5.0494

>AT22525 WP_006087376.1 NC_009998:64051-64386 [Shewanella baltica OS195]
MQNTMTYKGYHGSVEISPEDNILFGQVLFISPLINYEAETAKGLEQAFQEAINAYLADCAQQDIQPEKPCKGSLNVRLGH
DLHLAASIAAFQASTSTNEFIKRAVQKSVGL

Nucleotide

• Length: 336 bp

>AT22525 NC_009998:64051-64386 [Shewanella baltica OS195]
ATGCAAAATACAATGACATATAAGGGTTATCACGGCTCTGTAGAAATCAGCCCAGAGGATAATATTCTGTTTGGGCAGGT
GCTATTCATTTCACCGTTGATCAACTATGAGGCCGAAACAGCCAAAGGGTTAGAGCAAGCCTTTCAAGAGGCGATTAACG
CTTATCTTGCTGACTGTGCTCAACAGGACATTCAACCAGAGAAGCCTTGCAAGGGATCGCTTAATGTCAGATTAGGCCAT
GACTTGCATTTGGCTGCGTCTATCGCGGCATTTCAGGCATCGACTAGCACGAATGAGTTTATCAAAAGGGCAGTTCAAAA
AAGCGTGGGTTTGTAG

Structures

Toxin

• AlphaFold DB: A9L6F9