Detailed information of TA system TA022522

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 904490..905286
• Replicon: chromosome
• Accession: NC_009997
• Organism: Shewanella baltica OS195

Toxin (Protein)

• Gene name: -
• Uniprot ID: B8ECY2
• Locus tag: SBAL195_RS03900
• Protein ID: WP_011847801.1
• Coordinates: 904756..905286 (+)
• Length: 177 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A9L131
• Locus tag: SBAL195_RS03895
• Protein ID: WP_012196652.1
• Coordinates: 904490..904759 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBAL195_RS03875	899802..901994	+	2193	WP_012196650.1	TonB-dependent siderophore receptor	-
SBAL195_RS03880	902095..902769	+	675	WP_006086056.1	Fe2+-dependent dioxygenase	-
SBAL195_RS03885	903207..903692	+	486	WP_012196651.1	hypothetical protein	-
SBAL195_RS03890	903823..904287	+	465	WP_041411001.1	hypothetical protein	-
SBAL195_RS03895	904490..904759	+	270	WP_012196652.1	DUF1778 domain-containing protein	Antitoxin
SBAL195_RS03900	904756..905286	+	531	WP_011847801.1	GNAT family N-acetyltransferase	Toxin
SBAL195_RS03905	905612..906427	+	816	WP_012196653.1	hypothetical protein	-
SBAL195_RS03910	906411..906800	+	390	WP_080514245.1	HEPN domain-containing protein	-
SBAL195_RS25045	906875..907054	+	180	WP_150102373.1	hypothetical protein	-
SBAL195_RS03915	907120..907413	-	294	WP_012196656.1	hypothetical protein	-
SBAL195_RS03920	907410..907730	-	321	WP_012196657.1	hypothetical protein	-
SBAL195_RS03925	907727..907957	-	231	WP_011847800.1	hypothetical protein	-
SBAL195_RS03930	907954..908232	-	279	WP_012196658.1	hypothetical protein	-
SBAL195_RS03935	908233..908526	-	294	WP_012196659.1	hypothetical protein	-
SBAL195_RS03940	908557..908904	-	348	WP_012196660.1	hypothetical protein	-
SBAL195_RS03945	908930..909190	-	261	WP_006082040.1	pyocin activator PrtN family protein	-
SBAL195_RS03950	909187..909540	-	354	WP_012196661.1	hypothetical protein	-
SBAL195_RS03955	909693..909980	+	288	WP_048908671.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	895378..946696	51318

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (96-155)

Antitoxin

• Vibrio phage ICP1, Orf50 (5-81)

Sequences

Toxin

Protein

• Length: 177 a.a.
• Molecular weight: 19727.98 Da
• Isoelectric Point: 8.6014

>T22522 WP_011847801.1 NC_009997:904756-905286 [Shewanella baltica OS195]
VSYSKTFKELDKSQHDRASFDCGEAELNDFIQTQAAKHMQAGISRTMVLPAVTPLPNQKYPICSFYTIAPSSICRDTLPQ
AMGKKLPRYPIPVFLLAQLAVHKEFHGSGLGKASLIKALEYLWEINAHMRAYAIVVDCLTGQAESFYAKYGFEVLCEING
RVRMFIPMKTVGQLFT

Nucleotide

• Length: 531 bp

>T22522 NC_009997:904756-905286 [Shewanella baltica OS195]
GTGAGTTATTCCAAGACTTTCAAAGAATTGGATAAATCACAACACGATAGAGCATCATTTGACTGTGGCGAAGCAGAGTT
AAACGATTTTATCCAAACTCAAGCTGCGAAACACATGCAAGCAGGTATTAGCCGTACAATGGTTTTACCTGCTGTTACGC
CATTACCCAATCAAAAATATCCAATTTGCTCATTTTATACTATCGCCCCAAGTTCAATTTGCCGTGATACCTTACCGCAA
GCCATGGGTAAAAAGTTACCACGCTATCCCATTCCGGTTTTTCTGCTTGCTCAACTTGCTGTCCATAAAGAGTTTCATGG
TAGTGGGCTAGGTAAAGCTAGCTTAATCAAAGCACTAGAATACCTTTGGGAGATTAACGCTCACATGCGAGCTTATGCCA
TTGTTGTCGATTGCTTAACTGGCCAAGCTGAATCATTTTACGCTAAGTACGGTTTCGAGGTTCTTTGTGAAATCAACGGT
CGTGTAAGAATGTTTATTCCAATGAAAACAGTCGGTCAGTTGTTTACTTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9931.43 Da
• Isoelectric Point: 4.9059

>AT22522 WP_012196652.1 NC_009997:904490-904759 [Shewanella baltica OS195]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDSTQVIAEHESITVKADVFDQFIMACDEAKAPNKALREAV
AFTKRGEFK

Nucleotide

• Length: 270 bp

>AT22522 NC_009997:904490-904759 [Shewanella baltica OS195]
ATGGCGACTGCAAGACTTGATATCCGTTTGGATGAAGAGATCAAAGCTAAGGCTGAGAAAGCCTCGGCTTTGCTTGGTTT
AAAAAGCTTAACTGAATACGTTGTTCGCTTAATGGACGAAGATTCAACTCAGGTGATTGCTGAGCATGAAAGCATTACTG
TTAAAGCTGATGTATTCGACCAATTCATAATGGCTTGTGATGAGGCTAAGGCCCCGAACAAGGCATTGCGTGAAGCGGTT
GCATTTACTAAACGTGGTGAGTTTAAGTGA

Structures

Toxin

• AlphaFold DB: A3D8P0

Antitoxin

• AlphaFold DB: A9L131