Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1183533..1184151 Replicon chromosome
Accession NZ_CP087287
Organism Escherichia coli strain APEC 16-1068

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LO742_RS05680 Protein ID WP_001291435.1
Coordinates 1183533..1183751 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LO742_RS05685 Protein ID WP_000344800.1
Coordinates 1183777..1184151 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO742_RS05645 (1178820) 1178820..1179392 + 573 WP_000779831.1 YbaY family lipoprotein -
LO742_RS05650 (1179423) 1179423..1179734 - 312 WP_000409908.1 MGMT family protein -
LO742_RS05660 (1180113) 1180113..1180466 + 354 WP_000878140.1 DUF1428 domain-containing protein -
LO742_RS05665 (1180508) 1180508..1182058 - 1551 WP_274430193.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LO742_RS05670 (1182222) 1182222..1182692 - 471 WP_000136192.1 YlaC family protein -
LO742_RS05675 (1182808) 1182808..1183359 - 552 WP_000102543.1 maltose O-acetyltransferase -
LO742_RS05680 (1183533) 1183533..1183751 - 219 WP_001291435.1 HHA domain-containing protein Toxin
LO742_RS05685 (1183777) 1183777..1184151 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LO742_RS05690 (1184696) 1184696..1187845 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
LO742_RS05695 (1187868) 1187868..1189061 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T225219 WP_001291435.1 NZ_CP087287:c1183751-1183533 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T225219 NZ_CP121075:646223-646591 [Salmonella enterica subsp. enterica serovar Infantis]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTTGGCATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT225219 WP_000344800.1 NZ_CP087287:c1184151-1183777 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT225219 NZ_CP121075:646005-646226 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGATCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References