Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 125782..126425 Replicon plasmid pYUSHP29-2
Accession NZ_CP087282
Organism Leclercia adecarboxylata strain SH19PE29

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag LO739_RS24050 Protein ID WP_230431572.1
Coordinates 125782..126198 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag LO739_RS24055 Protein ID WP_230431573.1
Coordinates 126195..126425 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO739_RS24030 (LO739_24025) 120923..121942 - 1020 WP_230431570.1 alpha/beta hydrolase -
LO739_RS24035 (LO739_24030) 122641..123063 + 423 WP_117089457.1 MarR family transcriptional regulator -
LO739_RS24040 (LO739_24035) 123459..124931 + 1473 WP_230431571.1 aldehyde dehydrogenase family protein -
LO739_RS24045 (LO739_24040) 125026..125652 + 627 WP_230431594.1 TetR/AcrR family transcriptional regulator -
LO739_RS24050 (LO739_24045) 125782..126198 - 417 WP_230431572.1 type II toxin-antitoxin system VapC family toxin Toxin
LO739_RS24055 (LO739_24050) 126195..126425 - 231 WP_230431573.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LO739_RS24060 (LO739_24055) 126538..126789 + 252 WP_230431574.1 hypothetical protein -
LO739_RS24065 (LO739_24060) 126909..127484 - 576 WP_230431575.1 SLATT domain-containing protein -
LO739_RS24070 (LO739_24065) 127492..128820 - 1329 WP_230431576.1 nucleotidyltransferase -
LO739_RS24075 (LO739_24070) 129010..130377 - 1368 WP_230431577.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..132089 132089


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15186.48 Da        Isoelectric Point: 5.7444

>T225212 WP_230431572.1 NZ_CP087282:c126198-125782 [Leclercia adecarboxylata]
VNKTYMLDTNICSFIMREQPEAVLKRLEQAVLRNQRIVVSAITYSEMRFGATGPKASPRHTELVDEFCARLDAILPWDRA
AVDASTDVKVALRLAGTPIGPNDTLIAGHAIAAGAILVTNNVREFERVPGLVLEDWVN

Download         Length: 417 bp

>T225212 NZ_CP121074:14789-15121 [Salmonella enterica subsp. enterica serovar Infantis]
ATGGACAGAGGGGAAATCTGGCTCGTCTCACTGGATCCTACAGCCGGACATGAACAAAGCGGAAAACGTCCGGTACTTAT
CGTTTCTCCGGCATCATTTAATAAGTTCACCCGGTTACCCGTTGTCGTTCCCGTCACCAGCGGCGGAGACTTTGCCCGCA
CAGCCGGTTTTACCGTCTCCCTGGACGGCGCGGGAACAAAAACAACGGGTGTTATTCGCTGCGACCAGCCCAGAACGATT
GATATGGGTGCCCGGAATGGTAAGCGTCTGGAACGTATACCCGAAGCTGTCGTAAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8688.80 Da        Isoelectric Point: 4.4692

>AT225212 WP_230431573.1 NZ_CP087282:c126425-126195 [Leclercia adecarboxylata]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVTNEGRVDL

Download         Length: 231 bp

>AT225212 NZ_CP121074:14531-14788 [Salmonella enterica subsp. enterica serovar Infantis]
ATGTATACCACTCGTCTGAAAAAGGTTGGCGGATCCGTCATGCTGGCGGTTCCTCCCGCCGTGTTGAAAACGCTGGCTCT
GTCGACAGACAGCGAAGTGGGAATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAACTGCTGGCACAGTGCGATCCGCACGCCGAAATGAGCGATGAGGATAGGGAATGGATGGATGCGCCTGCAGTG
GGTAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References