Detailed information of TA system TA022521

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 824007..825548
• Replicon: chromosome
• Accession: NC_009997
• Organism: Shewanella baltica OS195

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A9L0C7
• Locus tag: SBAL195_RS03515
• Protein ID: WP_006086107.1
• Coordinates: 824247..825548 (+)
• Length: 434 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: SBAL195_RS03510
• Protein ID: WP_006086108.1
• Coordinates: 824007..824243 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBAL195_RS03495	821436..822611	+	1176	WP_006086111.1	HEAT repeat domain-containing protein	-
SBAL195_RS03500	822663..822848	-	186	WP_006086110.1	hypothetical protein	-
SBAL195_RS03505	822924..823163	-	240	WP_006086109.1	esterase	-
SBAL195_RS03510	824007..824243	+	237	WP_006086108.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
SBAL195_RS03515	824247..825548	+	1302	WP_006086107.1	HipA domain-containing protein	Toxin
SBAL195_RS03520	826064..826333	+	270	WP_006086106.1	hypothetical protein	-
SBAL195_RS03525	826863..827285	+	423	WP_006086105.1	hypothetical protein	-
SBAL195_RS03530	827398..828798	-	1401	WP_006086104.1	GGDEF domain-containing protein	-
SBAL195_RS03535	829172..829558	+	387	WP_006086103.1	carboxymuconolactone decarboxylase family protein	-
SBAL195_RS03540	829701..829952	-	252	WP_006083102.1	DUF2999 domain-containing protein	-
SBAL195_RS25040	829970..830194	+	225	WP_148228712.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (146-360)

Antitoxin

• Cro/C1-type helix-turn-helix domain (11-64)

Sequences

Toxin

Protein

• Length: 434 a.a.
• Molecular weight: 48702.88 Da
• Isoelectric Point: 5.1856

>T22521 WP_006086107.1 NC_009997:824247-825548 [Shewanella baltica OS195]
MSTSKKLTLEMHLGDLMIGELSFDATTDTFAVHYTKDWQQSGFPLSPTIPLDGTASSSQISMFLVNLLPENKGLDYLIES
LGVSKGNTFALIRAIGLDTAGAVAFVPKGTLLPETQLRPIKAEEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYN
GEEFAFAEGALSSTHIVKFEKYRHLVLNEFMTMRLAKAIGMNVANVDIVHFGDYKVLCVERFDRRYMPNEQRVLRRHIVD
SCQALGFSVSKKYERNFGSGRDVKDIREGVSFNRLFSLAVKCRNPVAAKQDMLQWALFNLLTGNADAHGKNYSFFMTPSG
MEPTPWYDLVSVAMYEDFEQQLAMAIDDEFDPNSIYAYQLAAFIDGLDLPRNLLISNLTTIARRIPQAIDGVISMLPALD
ENETSFVAHYKAQLLARCDRYLSFAAEVRDVEV

Nucleotide

• Length: 1302 bp

>T22521 NC_009997:824247-825548 [Shewanella baltica OS195]
ATGAGTACTTCCAAAAAGCTCACGTTAGAGATGCACCTCGGTGATTTAATGATCGGGGAGTTATCCTTTGATGCGACGAC
CGACACCTTTGCCGTACATTACACCAAAGACTGGCAACAAAGTGGATTCCCACTATCCCCAACAATTCCCTTAGATGGCA
CAGCAAGTAGCAGTCAGATATCGATGTTTTTGGTTAACTTATTACCGGAAAACAAAGGATTAGATTATCTAATTGAATCG
CTTGGCGTCTCCAAGGGAAATACCTTTGCCTTGATCCGTGCAATTGGTCTCGATACCGCAGGTGCTGTTGCTTTTGTTCC
TAAAGGGACTTTGCTGCCTGAAACACAATTACGGCCAATTAAGGCTGAAGAAGTTATTCAGCGAATTGAAGATCCCACAA
TGTGGCCGATGGAAATTTGGGACGGCAAACCTCGACTGTCGGTTGCGGGTGTGCAACCTAAATTAAACCTGTTTTATAAC
GGTGAAGAATTTGCATTTGCCGAAGGCGCACTGTCATCTACCCATATTGTTAAATTCGAAAAATATCGCCATTTAGTGCT
CAATGAATTTATGACGATGCGCTTAGCCAAGGCGATTGGAATGAATGTGGCTAATGTTGATATCGTTCATTTTGGAGATT
ACAAAGTACTCTGTGTCGAACGCTTTGACCGACGTTATATGCCAAATGAGCAAAGGGTATTAAGAAGGCATATTGTCGAT
AGCTGCCAAGCACTTGGTTTTAGTGTTAGCAAAAAATATGAACGTAATTTTGGTTCAGGGCGTGATGTTAAAGATATTCG
TGAAGGGGTAAGTTTTAACAGGCTCTTTAGTCTTGCTGTAAAATGTCGCAATCCAGTGGCTGCTAAGCAAGACATGTTGC
AATGGGCGCTGTTCAATTTACTGACCGGCAATGCCGATGCACACGGTAAAAACTATTCGTTTTTTATGACGCCAAGCGGA
ATGGAGCCAACTCCTTGGTACGATTTGGTCAGCGTGGCTATGTATGAAGATTTTGAACAACAGCTTGCTATGGCAATCGA
TGACGAATTTGATCCAAATAGCATTTACGCGTATCAATTGGCCGCATTTATTGATGGCTTAGATTTACCACGGAATTTAT
TAATCAGTAACTTAACGACAATAGCGCGAAGAATACCGCAGGCAATAGATGGTGTGATTTCAATGCTCCCGGCCCTCGAT
GAGAATGAAACATCATTTGTGGCTCATTACAAAGCGCAGTTGCTGGCGAGATGTGATCGTTACCTTAGTTTTGCCGCCGA
GGTCAGGGATGTCGAAGTGTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8574.91 Da
• Isoelectric Point: 7.9728

>AT22521 WP_006086108.1 NC_009997:824007-824243 [Shewanella baltica OS195]
MASRLNQQSLGLLIKERRKSAALTQDVAAMLCGVTKKTLIRVEKGEDVYISTVFKILDGLGIEIVSAQTSDTETNGWY

Nucleotide

• Length: 237 bp

>AT22521 NC_009997:824007-824243 [Shewanella baltica OS195]
ATGGCATCACGGCTAAATCAACAATCCCTCGGCTTGTTAATTAAAGAACGAAGGAAAAGTGCTGCTCTTACTCAAGACGT
GGCAGCCATGCTGTGCGGCGTAACCAAAAAAACGCTGATCCGAGTTGAAAAAGGTGAGGATGTTTATATCTCAACCGTAT
TCAAAATCCTTGATGGTCTGGGGATTGAGATCGTTTCGGCTCAAACCAGCGACACCGAAACTAACGGCTGGTATTAA

Structures

Toxin

• AlphaFold DB: A9L0C7