Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3935230..3935890 Replicon chromosome
Accession NZ_CP087280
Organism Leclercia adecarboxylata strain SH19PE29

Toxin (Protein)


Gene name cptA Uniprot ID A0A7H0FEK5
Locus tag LO739_RS18650 Protein ID WP_032613858.1
Coordinates 3935230..3935643 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6G7TIV6
Locus tag LO739_RS18655 Protein ID WP_032613860.1
Coordinates 3935624..3935890 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO739_RS18630 (LO739_18625) 3931228..3932961 - 1734 WP_230430982.1 single-stranded-DNA-specific exonuclease RecJ -
LO739_RS18635 (LO739_18630) 3932967..3933680 - 714 WP_230430983.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LO739_RS18640 (LO739_18635) 3933706..3934602 - 897 WP_230430984.1 site-specific tyrosine recombinase XerD -
LO739_RS18645 (LO739_18640) 3934704..3935225 + 522 WP_230430985.1 flavodoxin FldB -
LO739_RS18650 (LO739_18645) 3935230..3935643 - 414 WP_032613858.1 protein YgfX Toxin
LO739_RS18655 (LO739_18650) 3935624..3935890 - 267 WP_032613860.1 FAD assembly factor SdhE Antitoxin
LO739_RS18660 (LO739_18655) 3936195..3937175 + 981 WP_230430986.1 tRNA-modifying protein YgfZ -
LO739_RS18665 (LO739_18660) 3937305..3937964 - 660 WP_230430987.1 hemolysin III family protein -
LO739_RS18670 (LO739_18665) 3938130..3938441 - 312 WP_230430988.1 N(4)-acetylcytidine aminohydrolase -
LO739_RS18675 (LO739_18670) 3938494..3939225 + 732 WP_151586876.1 MurR/RpiR family transcriptional regulator -
LO739_RS18680 (LO739_18675) 3939338..3940771 + 1434 WP_130588237.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16231.98 Da        Isoelectric Point: 10.6531

>T225208 WP_032613858.1 NZ_CP087280:c3935643-3935230 [Leclercia adecarboxylata]
VVLWQSDLRVSWRAQWMSLLLHGLVAACILLIPWPLSYTPLWLILLSLVVFDSVRSQRRINSRQGEIKLFMDSRLQWQGS
EWEIIGTPWMLNSGMMLRLRKGDGKRYQHLWLSADSMDEGEWRDLRRMLSQQPTHGR

Download         Length: 414 bp

>T225208 NZ_CP121073:3717705-3717962 [Salmonella enterica subsp. enterica serovar Infantis]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCAGTTACTCACATATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10539.06 Da        Isoelectric Point: 4.6787

>AT225208 WP_032613860.1 NZ_CP087280:c3935890-3935624 [Leclercia adecarboxylata]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKKLFIRLLENDDPDLFNWLMNHGEPADAELQRMVLLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT225208 NZ_CP121073:c3717880-3717548 [Salmonella enterica subsp. enterica serovar Infantis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCTCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0FEK5

Antitoxin

Source ID Structure
AlphaFold DB A0A6G7TIV6

References