Detailed information of TA system TA022520

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipB(antitoxin)
• Location: 432234..432694
• Replicon: chromosome
• Accession: NC_009997
• Organism: Shewanella baltica OS195

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A9KXZ5
• Locus tag: SBAL195_RS01990
• Protein ID: WP_011982214.1
• Coordinates: 432515..432694 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: SBAL195_RS01985
• Protein ID: WP_006079858.1
• Coordinates: 432234..432515 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBAL195_RS01960	427451..427818	-	368	Protein_373	hypothetical protein	-
SBAL195_RS01965	427983..428882	-	900	WP_012196577.1	LysR family transcriptional regulator	-
SBAL195_RS01970	429122..429859	+	738	WP_012196578.1	pyrimidine 5'-nucleotidase	-
SBAL195_RS01975	429894..430532	-	639	WP_006086643.1	multidrug MFS transporter	-
SBAL195_RS01980	430714..431847	+	1134	WP_012196579.1	hypothetical protein	-
SBAL195_RS01985	432234..432515	+	282	WP_006079858.1	helix-turn-helix domain-containing protein	Antitoxin
SBAL195_RS01990	432515..432694	+	180	WP_011982214.1	HipA N-terminal domain-containing protein	Toxin
SBAL195_RS01995	432752..433615	-	864	WP_006079861.1	YicC family protein	-
SBAL195_RS02000	434153..434866	+	714	WP_006079862.1	ribonuclease PH	-
SBAL195_RS02005	435043..435684	+	642	WP_006086671.1	orotate phosphoribosyltransferase	-
SBAL195_RS02010	435911..436561	-	651	WP_006079864.1	GTP cyclohydrolase I FolE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-52)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6576.72 Da
• Isoelectric Point: 10.1058

>T22520 WP_011982214.1 NC_009997:432515-432694 [Shewanella baltica OS195]
MAVLDVYMNGYLVRELTKSSTGSHQFAYAQQWLAIPGSRPISLSMLLRKQACKGFFPAP

Nucleotide

• Length: 180 bp

>T22520 NC_009997:432515-432694 [Shewanella baltica OS195]
ATGGCAGTGCTTGATGTTTATATGAATGGCTACCTTGTGCGTGAATTGACCAAATCATCCACAGGCTCTCATCAGTTTGC
GTATGCCCAGCAATGGCTAGCTATACCCGGTAGTCGCCCAATTTCTTTGTCTATGCTGCTACGCAAGCAAGCTTGTAAAG
GTTTTTTTCCTGCGCCATAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10697.12 Da
• Isoelectric Point: 7.0147

>AT22520 WP_006079858.1 NC_009997:432234-432515 [Shewanella baltica OS195]
MKVTNAKQLSTYLKDARLNAQLSQSKVASKVGIRQDTVSSFELNPDSTKLETLFKILSALNLELDIKVRNPQLVDERRHD
NATVPEQEWKEEW

Nucleotide

• Length: 282 bp

>AT22520 NC_009997:432234-432515 [Shewanella baltica OS195]
ATGAAGGTGACCAACGCAAAGCAGTTGAGTACGTATCTAAAAGATGCGCGGCTGAACGCGCAGCTCTCGCAAAGCAAGGT
GGCGAGCAAGGTAGGTATTCGCCAGGATACCGTTTCAAGCTTTGAGTTGAACCCGGATTCGACCAAATTAGAAACGCTGT
TTAAGATCCTTTCTGCATTAAACCTAGAGCTAGATATAAAGGTTCGGAATCCACAGCTGGTGGATGAGCGCCGCCATGAT
AACGCCACAGTGCCTGAGCAAGAATGGAAGGAGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: A9KXZ5